Publication Name	World Journal of Rheumatology
Manuscript ID	12240
Country	United Kingdom

Received	2014-06-28 21:44
Peer-Review Started	2014-06-29 15:35
To Make the First Decision	2014-08-28 15:01
Return for Revision	2014-09-01 08:50
Revised	2014-09-10 19:48
Second Decision	2014-10-10 18:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-10 18:24
Articles in Press	2014-10-10 18:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-04 16:43
Publish the Manuscript Online	2014-11-14 13:15

ISSN	2220-3214 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Rheumatology
Manuscript Type	Review
Article Title	Oral creatine supplementation: A potential adjunct therapy for rheumatoid arthritis patients
Manuscript Source	Invited Manuscript
All Author List	Thomas J Wilkinson, Thomas D O’Brien and Andrew B Lemmey
Funding Agency and Grant Number
Corresponding Author	Andrew B Lemmey, Professor, School of Sport, Health and Exercise Sciences, Bangor University, George Building, Normal Site, Holyhead Road, Wales LL57 2PZ, United Kingdom. a.b.lemmey@bangor.ac.uk
Key Words	Creatine supplementation; Nutritional supplement; Rheumatoid arthritis; Rheumatoid cachexia; Physical function
Core Tip	Creatine supplementation primarily improves physical function by enhancing the re-synthesis of adenosine triphosphate via increased stores of phosphocreatine in the muscle. Through this pathway it provides greater levels of energy during physical activity and improves recovery. Creatine also augments muscle protein synthesis, thereby increasing muscle mass. These dual effects increase strength, reduce fatigue, and thereby improve function. In patients with conditions such as rheumatoid arthritis that are characterised by muscle loss and subsequent reductions in strength and physical function, creatine offers a potential therapeutic intervention for augmenting muscle mass and function that is safe, easy and inexpensive to administer.
Publish Date	2014-11-14 13:15
Citation	Wilkinson TJ, O’Brien TD, Lemmey AB. Oral creatine supplementation: A potential adjunct therapy for rheumatoid arthritis patients. World J Rheumatol 2014; 4(3): 22-34
URL	http://www.wjgnet.com/2220-3214/full/v4/i3/22.htm
DOI	http://dx.doi.org/10.5499/wjr.v4.i3.22

Full Article (PDF)	WJR-4-22.pdf
Full Article (Word)	WJR-4-22.doc
Manuscript File	12240-Review.docx
Answering Reviewers	12240-Answering reviewers.pdf
Copyright License Agreement	12240-Copyright assignment.pdf
Peer-review Report	12240-Peer review(s).pdf
Scientific Misconduct Check	12240-CrossCheck.jpg
Scientific Editor Work List	12240-Scientific editor work list.pdf