Publication Name	World Journal of Pharmacology
Manuscript ID	12263
Country	Portugal

Received	2014-06-29 13:50
Peer-Review Started	2014-06-29 19:13
To Make the First Decision	2014-08-14 14:36
Return for Revision	2014-08-18 10:37
Revised	2014-09-01 05:08
Second Decision	2014-09-24 16:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-24 16:23
Articles in Press	2014-09-24 16:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-28 17:55
Publish the Manuscript Online	2014-12-12 11:14

ISSN	2220-3192 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Review
Article Title	Phosphoprotein phosphatase 1-interacting proteins as therapeutic targets in prostate cancer
Manuscript Source	Invited Manuscript
All Author List	Juliana Felgueiras and Margarida Fardilha
Funding Agency and Grant Number	Funding Agency Grant Number Fundação para a Ciência e Tecnologia PTDC/QUI-BIQ/118492/2010 Fundo Europeu de Desenvolvimento Regional, Portugal FCOMP-01-0124-FEDER-020895
Corresponding Author	Margarida Fardilha, PhD, Laboratory of Signal Transduction, Centre for Cell Biology, Biology Department and Health Sciences Department, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal. mfardilha@ua.pt
Key Words	Prostate cancer; Reversible phosphorylation; Phosphoprotein phosphatase 1; PPP1-interacting proteins; Protein complexes; Therapeutic targets
Core Tip	Protein kinases and phosphatases are challenging and valuable therapeutic targets for cancer. Here, we revise the relevance of phosphoprotein phosphatase 1 and its interactors for prostate carcinogenesis. Although only 4 complexes are characterized in human prostate cancer models, 81 additional interactors are expressed in human prostate tissue and, at least, 29 of which are involved in prostate carcinogenesis. This complex network has promising roles in the development of new therapies for prostate cancer. Therefore, efforts should be made in order to characterize their biological significance in prostate carcinogenesis.
Publish Date	2014-12-12 11:14
Citation	Felgueiras J, Fardilha M. Phosphoprotein phosphatase 1-interacting proteins as therapeutic targets in prostate cancer. World J Pharmacol 2014; 3(4): 120-139
URL	http://www.wjgnet.com/2220-3192/full/v3/i4/120.htm
DOI	http://dx.doi.org/10.5497/wjp.v3.i4.120

Full Article (PDF)	WJP-3-120.pdf
Full Article (Word)	WJP-3-120.doc
Manuscript File	12263-Review.docx
Answering Reviewers	12263-Answering reviewers.pdf
Copyright License Agreement	12263-Copyright assignment.pdf
Peer-review Report	12263-Peer review(s).pdf
Scientific Misconduct Check	12263-CrossCheck.jpg
Scientific Editor Work List	12263-Scientific editor work list.pdf