Publication Name	World Journal of Gastroenterology
Manuscript ID	12316
Country	Netherlands

Received	2014-07-03 09:48
Peer-Review Started	2014-07-03 13:53
To Make the First Decision	2014-07-21 13:03
Return for Revision	2014-07-23 14:11
Revised	2014-08-23 06:26
Second Decision	2014-11-17 12:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-11-19 09:33
Articles in Press	2014-11-19 09:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-22 09:17
Publish the Manuscript Online	2015-01-07 11:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Systematic mechanism-orientated approach to chronic pancreatitis pain
Manuscript Source	Invited Manuscript
All Author List	Stefan AW Bouwense, Marjan de Vries, Luuk TW Schreuder, Søren S Olesen, Jens B Frøkjær, Asbjørn M Drewes, Harry van Goor and Oliver HG Wilder-Smith
Funding Agency and Grant Number
Corresponding Author	Oliver HG Wilder-Smith, MD, PhD, DSc, Department of Anaesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, 6500HB Gelderland, The Netherlands. oliver.wilder-smith@radboudumc.nl
Key Words	Chronic pancreatitis; Pain; Pain treatment; Central sensitization; Quantitative sensory testing; Electroencephalograpy; Magnetic resonance imaging
Core Tip	Pain in chronic pancreatitis (CP) shows many similarities with other visceral pain syndromes. CP pain frequently leads to peripheral and central sensitization. When the latter is present, treating the nociceptive focus, with i.e., analgesic therapy, surgical or endoscopic procedures for local complications may fail even after technically successful procedures. In this case, treatment must be aimed at the central nervous system (CNS). Suitable tools to visualize altered central processing include quantitative sensory testing, electroencephalograpy and magnetic resonance imaging. Future research should be aimed at the circumstances under which CNS processing changes and how this is influenced by pain and therapies.
Publish Date	2015-01-07 11:07
Citation	Bouwense SA, de Vries M, Schreuder LT, Olesen SS, Frøkjær JB, Drewes AM, van Goor H, Wilder-Smith OH. Systematic mechanism-orientated approach to chronic pancreatitis pain. World J Gastroenterol 2015; 21(1): 47-59
URL	http://www.wjgnet.com/1007-9327/full/v21/i1/47.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i1.47

Full Article (PDF)	WJG-21-47.pdf
Full Article (Word)	WJG-21-47.doc
Manuscript File	12316-Review.docx
Answering Reviewers	12316-Answering reviewers.pdf
Copyright License Agreement	12316-Copyright assignment.pdf
Peer-review Report	12316-Peer reviews.pdf
Scientific Misconduct Check	12316-CrossCheck.jpg
Scientific Editor Work List	12316-Scientific editor work list.pdf