BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
2/11/2015 4:38:00 PM | Browse: 1189 | Download: 1573
 |
Received |
|
2014-07-03 09:34 |
|
Peer-Review Started |
|
2014-07-03 19:24 |
|
To Make the First Decision |
|
2014-08-06 17:16 |
|
Return for Revision |
|
2014-08-14 11:48 |
|
Revised |
|
2014-08-25 14:23 |
|
Second Decision |
|
2014-10-15 12:37 |
 |
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2014-10-15 17:47 |
|
Articles in Press |
|
2014-10-15 18:01 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
2014-10-25 21:51 |
|
Typeset the Manuscript |
|
2015-02-02 08:16 |
|
Publish the Manuscript Online |
|
2015-02-11 16:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Retrospective Study |
| Article Title |
Natural YMDD-motif mutants affect clinical course of lamivudine in chronic hepatitis B
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
You-Wen Tan, Yun Ye, Guo-Hong Ge, Wei Zhao, Jian-He Gan, Yun Zhao, Zhi-Lin Niu, Dong-Jun Zhang, Li Chen, Xue-Jun Yu and Li-Jun Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhenjiang Municipal Science and Technology Commission |
SH2009016 |
|
| Corresponding Author |
Dr. You-Wen Tan, Associate Professor, Department of Liver Diseases, the Third Hospital of Zhenjiang Affiliated to Jiangsu University, No. 300, Daijiamen, Runzhou Distinct, Zhenjiang 212000, Jiangsu Province,
China. tyw915@sina.com
|
| Key Words |
Chronic hepatitis B; Mutation; Tyrosine-methionine-aspartic acid-aspartic acid; Lamivudine; Virological breakthrough |
| Core Tip |
Although tyrosine-methionine-aspartic acid-aspartic acid (YMDD) motif mutation is considered to occur secondary to the use of lamivudine, it has become increasingly apparent that YMDD mutations exist in nature. A total of 1268 chronic hepatitis B (CHB) patients were recruited from six centers. YMDD mutations were detected using Inno-Lipa hepatitis B virus (HBV) drug resistance line probe assay in 288 (22.71%) of the 1268 CHB patients. Our study demonstrated that lamivudine therapy was well tolerated by Chinese CHB patients with natural YMDD mutations and led to reductions in transaminase levels and HBV-DNA loss. However, breakthrough hepatitis tended to occur in patients with natural YMDD mutations. |
| Publish Date |
2015-02-11 16:38 |
| Citation |
Tan YW, Ye Y, Ge GH, Zhao W, Gan JH, Zhao Y, Niu ZL, Zhang DJ, Chen L, Yu XJ, Yang LJ. Natural YMDD-motif mutants affect clinical course of lamivudine in chronic hepatitis B. World J Gastroenterol 2015; 21(7): 2089-2095 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i7/2089.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i7.2089 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
