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2/11/2015 4:38:00 PM | Browse: 362 | Download: 443
Publication Name World Journal of Gastroenterology
Manuscript ID 12346
Country of Manuscript Source China
Received
2014-07-03 09:34
Peer-Review Started
2014-07-03 19:24
To Make the First Decision
2014-08-06 17:16
Return for Revision
2014-08-14 11:48
Revised
2014-08-25 14:23
Second Decision
2014-10-15 12:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-10-15 17:47
Articles in Press
2014-10-15 18:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-10-25 21:51
Typeset the Manuscript
2015-02-02 08:16
Publish the Manuscript Online
2015-02-11 16:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Infectious Diseases
Manuscript Type Retrospective Study
Article Title Natural YMDD-motif mutants affect clinical course of lamivudine in chronic hepatitis B
Manuscript Source Unsolicited Manuscript
All Author List You-Wen Tan, Yun Ye, Guo-Hong Ge, Wei Zhao, Jian-He Gan, Yun Zhao, Zhi-Lin Niu, Dong-Jun Zhang, Li Chen, Xue-Jun Yu and Li-Jun Yang
Funding Agency and Grant Number
Funding Agency Grant Number
Zhenjiang Municipal Science and Technology Commission SH2009016
Corresponding author Dr. You-Wen Tan, Associate Professor, Department of Liver Diseases, the Third Hospital of Zhenjiang Affiliated to Jiangsu University, No. 300, Daijiamen, Runzhou Distinct, Zhenjiang 212000, Jiangsu Province, China. tyw915@sina.com
Keywords Chronic hepatitis B; Mutation; Tyrosine-methionine-aspartic acid-aspartic acid; Lamivudine; Virological breakthrough
Core Tip Although tyrosine-methionine-aspartic acid-aspartic acid (YMDD) motif mutation is considered to occur secondary to the use of lamivudine, it has become increasingly apparent that YMDD mutations exist in nature. A total of 1268 chronic hepatitis B (CHB) patients were recruited from six centers. YMDD mutations were detected using Inno-Lipa hepatitis B virus (HBV) drug resistance line probe assay in 288 (22.71%) of the 1268 CHB patients. Our study demonstrated that lamivudine therapy was well tolerated by Chinese CHB patients with natural YMDD mutations and led to reductions in transaminase levels and HBV-DNA loss. However, breakthrough hepatitis tended to occur in patients with natural YMDD mutations.
Publish Date 2015-02-11 16:38
Citation Tan YW, Ye Y, Ge GH, Zhao W, Gan JH, Zhao Y, Niu ZL, Zhang DJ, Chen L, Yu XJ, Yang LJ. Natural YMDD-motif mutants affect clinical course of lamivudine in chronic hepatitis B. World J Gastroenterol 2015; 21(7): 2089-2095
Url http://www.wjgnet.com/1007-9327/full/v21/i7/2089.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i7.2089
Full Article (PDF) WJG-21-2089.pdf
Full Article (Word) WJG-21-2089.doc
Manuscript File 12346-Review.docx
Answering Reviewers 12346-Answering reviewers.pdf
Copyright License Agreement 12346-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 12346-Language certificate.pdf
Peer-review Report 12346-Peer reviews.pdf
Scientific Misconduct Check 12346-CrossCheck.jpg
Scientific Editor Work List 12346-Scientific editor work list.pdf