Publication Name	World Journal of Gastroenterology
Manuscript ID	12721
Country	Japan

Received	2014-07-23 18:17
Peer-Review Started	2014-07-24 18:06
To Make the First Decision	2014-08-15 12:19
Return for Revision	2014-08-22 16:01
Revised	2014-11-13 23:13
Second Decision	2014-12-02 07:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-16 10:08
Articles in Press	2014-12-16 10:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-02-07 17:31
Typeset the Manuscript	2015-03-08 21:02
Publish the Manuscript Online	2015-03-19 16:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Novel CD9 targeted therapies in gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Yoko Murayama, Kenji Oritani and Shusaku Tsutsui
Funding Agency and Grant Number
Corresponding Author	Yoko Murayama, MD, PhD, Department of Gastroenterology and Hepatology, Itami City Hospital, 1-100 Koyaike, Itami 664-8540, Japan. murayama@hosp.itami.hyogo.jp
Key Words	CD9; Tetraspanin; Gastric cancer; Tumorigenicity; Target therapies
Core Tip	Tetraspanin CD9 is a cell surface protein with four transmembrane domains and found in multiple organs. Although CD9 was primarily identified as a tumor suppressor, it exhibits diverse functions through the association with various partner proteins. CD9 relates to tumor proliferation, apoptosis, migration, adhesion, and angiogenesis, therefore involving in several steps of tumor formation; communication with the environment, dissemination, and metastasis. In this review, we describe the possibility of CD9 manipulation as a novel therapeutic strategy to improve clinical outcome in gastric cancer.
Publish Date	2015-03-19 16:57
Citation	Murayama Y, Oritani K, Tsutsui S. Novel CD9-targeted therapies in gastric cancer. World J Gastroenterol 2015; 21(11): 3206-3213
URL	http://www.wjgnet.com/1007-9327/full/v21/i11/3206.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i11.3206

Full Article (PDF)	WJG-21-3206.pdf
Full Article (Word)	WJG-21-3206.doc
Manuscript File	12721-Review.docx
Answering Reviewers	12721-Answering reviewers.pdf
Copyright License Agreement	12721-Copyright assignment.pdf
Peer-review Report	12721-Peer review(s).pdf
Scientific Misconduct Check	12721-CrossCheck.jpg
Scientific Editor Work List	12721-Scientific editor work list.pdf