BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
2/9/2015 5:58:00 PM | Browse: 1079 | Download: 1413
 |
Received |
|
2014-07-23 20:21 |
|
Peer-Review Started |
|
2014-07-24 09:47 |
 |
First Decision by Editorial Office Director |
|
|
|
Return for Revision |
|
2014-09-17 18:04 |
|
Revised |
|
|
|
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2014-11-17 11:44 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2014-11-19 09:38 |
|
Articles in Press |
|
2014-11-19 09:48 |
|
Edit the Manuscript by Language Editor |
|
2014-12-09 00:01 |
|
Typeset the Manuscript |
|
2015-01-25 20:07 |
|
Publish the Manuscript Online |
|
2015-02-09 17:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanism involved in Danshen-induced fluid secretion in salivary glands
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fei Wei, Mu-Xin Wei and Masataka Murakami |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institute for Physiological Sciences and Graduate University for Advanced Studies |
|
|
| Corresponding Author |
Masataka Murakami, Associate Professor, Division of Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 5-1 Higashiyama, Myoudaiji-cho, Okazaki 444-8787, Japan. masataka@nips.ac.jp |
| Key Words |
Salivary fluid secretion; Xerostomia; Chinese herb; Danshen; Submandibular gland; Oxygen consumption; Extracellular Ca2+ |
| Core Tip |
Perfusion of rat submandibular glands allowed for the measurement of fluid secretion and oxygen consumption during Danshen stimulation, which induced a large salivary fluid secretion. Ouabain (Na+/K+ ATPase inhibitor) and bumetanide (NKCC1 inhibitor), inhibited fluid secretion and oxygen consumption significantly, indicating that Danshen has a similar basic mechanism for secretion. Receptor blockers indicated that Danshen does not bind with M3 or a1 receptors. These findings suggest that the mechanism for Danshen-induced fluid secretion could be different from that induced by carbamylcholine. Accordingly, Danshen may avoid the systemic side effects caused by muscarinic drugs in the treatment of xerostomia. |
| Publish Date |
2015-02-09 17:58 |
| Citation |
Wei F, Wei MX, Murakami M. Mechanism involved in Danshen-induced fluid secretion in salivary glands. World J Gastroenterol 2015; 21(5): 1444-1456 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i5/1444.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i5.1444 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
