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Articles Published Processes
2/9/2015 5:58:00 PM | Browse: 880 | Download: 1023
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Received |
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2014-07-23 20:21 |
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Peer-Review Started |
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2014-07-24 09:47 |
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To Make the First Decision |
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2014-09-15 17:58 |
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Return for Revision |
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2014-09-17 18:04 |
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Revised |
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Second Decision |
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2014-11-17 11:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-19 09:38 |
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Articles in Press |
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2014-11-19 09:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-12-09 00:01 |
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Typeset the Manuscript |
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2015-01-25 20:07 |
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Publish the Manuscript Online |
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2015-02-09 17:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanism involved in Danshen-induced fluid secretion in salivary glands
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fei Wei, Mu-Xin Wei and Masataka Murakami |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institute for Physiological Sciences and Graduate University for Advanced Studies |
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| Corresponding Author |
Masataka Murakami, Associate Professor, Division of Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 5-1 Higashiyama, Myoudaiji-cho, Okazaki 444-8787, Japan. masataka@nips.ac.jp |
| Key Words |
Salivary fluid secretion; Xerostomia; Chinese herb; Danshen; Submandibular gland; Oxygen consumption; Extracellular Ca2+ |
| Core Tip |
Perfusion of rat submandibular glands allowed for the measurement of fluid secretion and oxygen consumption during Danshen stimulation, which induced a large salivary fluid secretion. Ouabain (Na+/K+ ATPase inhibitor) and bumetanide (NKCC1 inhibitor), inhibited fluid secretion and oxygen consumption significantly, indicating that Danshen has a similar basic mechanism for secretion. Receptor blockers indicated that Danshen does not bind with M3 or a1 receptors. These findings suggest that the mechanism for Danshen-induced fluid secretion could be different from that induced by carbamylcholine. Accordingly, Danshen may avoid the systemic side effects caused by muscarinic drugs in the treatment of xerostomia. |
| Publish Date |
2015-02-09 17:58 |
| Citation |
Wei F, Wei MX, Murakami M. Mechanism involved in Danshen-induced fluid secretion in salivary glands. World J Gastroenterol 2015; 21(5): 1444-1456 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i5/1444.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i5.1444 |
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