Publication Name	World Journal of Stem Cells
Manuscript ID	12736
Country	United States

Received	2014-07-24 08:45
Peer-Review Started	2014-07-24 16:17
To Make the First Decision	2014-08-28 14:41
Return for Revision	2014-08-29 14:07
Revised	2014-09-03 23:02
Second Decision	2014-09-17 14:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-17 14:36
Articles in Press	2014-09-17 14:36
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-09-24 18:37
Typeset the Manuscript	2014-12-22 11:03
Publish the Manuscript Online	2015-01-14 11:53

ISSN	1948-0210 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Review
Article Title	Alternative splicing: An important mechanism in stem cell biology
Manuscript Source	Invited Manuscript
All Author List	Kenian Chen, Xiaojing Dai and Jiaqian Wu
Funding Agency and Grant Number
Corresponding Author	Jiaqian Wu, PhD, The Vivian L Smith Department of Neurosurgery, The Center for Stem Cell and Regenerative Medicine, University of Texas Medical School at Houston, 6431 Fannin St, Houston, TX 77030, United States. jiaqian.wu@uth.tmc.edu
Key Words	Alternative splicing; Stem cell; Pluripotency; Differentiation; Splicing factor
Core Tip	Alternative splicing (AS) produces multiple transcript isoforms from a single gene, and the regulation of cell-type-specific splicing pattern is crucial for the properties and functions of cells, including pluripotent stem cells. A better understanding of the role of AS in stem cell pluripotency maintenance and differentiation will offer potential new approaches for enhancing the production of induced pluripotent stem cells and/or better control of cell differentiation for research or therapeutic purposes. In this brief review, we provide a timely update of recent studies related to stem cell regulation and splicing in a genome-wide scale.
Publish Date	2015-01-14 11:53
Citation	Chen K, Dai X, Wu J. Alternative splicing: An important mechanism in stem cell biology. World J Stem Cells 2015; 7(1): 1-10
URL	http://www.wjgnet.com/1948-0210/full/v7/i1/1.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i1.1

Manuscript File	12736-Review.docx
Answering Reviewers	12736-Answering reviewers.pdf
Copyright License Agreement	12736-Copyright assignment.pdf
Peer-review Report	12736-Peer review(s).pdf
Scientific Misconduct Check	12736-CrossCheck.jpg
Scientific Editor Work List	12736-Scientific editor work list.pdf