Publication Name	World Journal of Stem Cells
Manuscript ID	12774
Country	United States

Received	2014-07-25 18:02
Peer-Review Started	2014-07-26 22:36
To Make the First Decision	2014-08-14 14:54
Return for Revision	2014-08-14 20:12
Revised	2014-08-27 03:52
Second Decision	2014-09-10 13:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-10 14:07
Articles in Press	2014-09-10 14:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-22 17:35
Publish the Manuscript Online	2014-09-28 14:56

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Minireviews
Article Title	Stem cells in gastrointestinal cancers: The road less travelled
Manuscript Source	Invited Manuscript
All Author List	Sameh Mikhail and Amer Zeidan
Funding Agency and Grant Number
Corresponding Author	Amer Zeidan, MBBS, MhS, Yale Comprehensive Cancer Center, 333 Cedar street, PO. Box 208028, New Haven, CT, 06520-8028, United States. amer.zeidan@yale.edu
Key Words	Cancer stem cells; CD 133+; WNT/β-catenin; Transformation growth factor-beta; Hedgehog; Notch
Core Tip	Cancer stem cells (CSC) are thought to be malignant cells that have the capacity to initiate and maintain tumor growth and survival. Several studies have explored the role of dysregulation of the Wnt/β- catenin, tranformation growth factor-beta and hedhog pathways in generation of CSC. The exact machismo of their development, however, remains unknown. Several investigators have researched modalities to identify and target CSC. In this review, we summarize the recent evidence exploring the machanisms of development, identification and targeting of CSC in gastrointestinal malignancies.
Publish Date	2014-09-28 14:56
Citation	Mikhail S, Zeidan A. Stem cells in gastrointestinal cancers: The road less travelled. World J Stem Cells 2014; 6(5): 606-613
URL	http://www.wjgnet.com/1948-0210/full/v6/i5/606.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i5.606

Full Article (PDF)	WJSC-6-606.pdf
Full Article (Word)	WJSC-6-606.doc
Manuscript File	RevisedCSCinGI sm 8 21 14.docx
Answering Reviewers	12774-Answering reviewers.pdf
Copyright License Agreement	12774-Copyright assignment.pdf
Peer-review Report	12774-Peer review(s).pdf
Scientific Misconduct Check	12774-CrossCheck.jpg
Scientific Editor Work List	12774-Scientific editor work list.pdf