Publication Name	World Journal of Stem Cells
Manuscript ID	12775
Country	New Zealand

Received	2014-07-25 18:04
Peer-Review Started	2014-07-26 22:43
To Make the First Decision	2014-08-14 14:54
Return for Revision	2014-08-14 20:21
Revised	2014-08-20 13:00
Second Decision	2014-09-01 15:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-09-01 15:23
Articles in Press	2014-09-01 15:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-15 12:55
Publish the Manuscript Online	2014-09-25 12:31

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Ophthalmology
Manuscript Type	Review
Article Title	Limbal stem cells: Central concepts of corneal epithelial homeostasis
Manuscript Source	Invited Manuscript
All Author List	Jinny J Yoon, Salim Ismail and Trevor Sherwin
Funding Agency and Grant Number	Funding Agency Grant Number Save Sight Society New Zealand Auckland Medical Research Foundation
Corresponding Author	Trevor Sherwin, PhD, Associate Professor, Department of Ophthalmology, University of Auckland, Private Bag 92019, Auckland 1020, New Zealand. t.sherwin@auckland.ac.nz
Key Words	Limbal stem cell; Corneal epithelium; XYZ hypothesis; Corneal homeostasis; Corneal wound repair
Core Tip	It is a long held belief that stem cells reside only at the limbus. However, there are recent reports that present evidence of corneal repair and maintenance independent of limbal involvement. These findings call to light the possibility of previously undiscovered reservoirs of corneal stem/progenitor cells located at the central and peripheral cornea. A new secondary reservoir of stem cells has a significant clinical implication as new therapeutics for corneal degenerative disorders. This review outlines the historic evidence for limbal stem cells and discusses the role of these putative central and peripheral corneal stems cells in corneal homeostasis.
Publish Date	2014-09-25 12:31
Citation	Yoon JJ, Ismail S, Sherwin T. Limbal stem cells: Central concepts of corneal epithelial homeostasis. World J Stem Cells 2014; 6(4): 391-403
URL	http://www.wjgnet.com/1948-0210/full/v6/i4/391.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i4.391

Full Article (PDF)	WJSC-6-391.pdf
Full Article (Word)	WJSC-6-391.doc
Manuscript File	12775-Review.docx
Answering Reviewers	12775-Answering reviewers.pdf
Copyright License Agreement	12775-Copyright assignment.pdf
Peer-review Report	12775-Peer review(s).pdf
Scientific Misconduct Check	12775-CrossCheck.jpg
Scientific Editor Work List	12775-Scientific editor work list.pdf