Publication Name	World Journal of Stem Cells
Manuscript ID	12830
Country	United States

Received	2014-07-29 10:58
Peer-Review Started	2014-08-11 17:14
To Make the First Decision	2014-09-04 09:27
Return for Revision	2014-09-04 11:27
Revised	2014-09-17 00:00
Second Decision	2014-09-17 09:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-17 09:52
Articles in Press	2014-09-17 09:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-22 17:36
Publish the Manuscript Online	2014-09-28 14:56

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Minireviews
Article Title	Stem cell biology in thyroid cancer: Insights for novel therapies
Manuscript Source	Invited Manuscript
All Author List	Parisha Bhatia, Koji Tsumagari, Zakaria Y Abd Elmageed, Paul Friedlander, Joseph F Buell and Emad Kandil
Funding Agency and Grant Number
Corresponding Author	Emad Kandil, MD, FACS, Departments of Surgery, Tulane University School of Medicine, 1430 Tulane Avenue, SL 59, New Orleans, LA 70112, United States. ekandil@tulane.edu
Key Words	Stem cells; Cancer Stem cells; Thyroid Neoplasms; Carcinogenesis; Cell Differentiation; Epithelial-Mesenchymal transition
Core Tip	The concept of cancer stem cells in thyroid gland tumors has recently evolved. Since this sub-population of cells appear to have a potential for self-renewal and cell differentiation, their role envisions newer ideas in the field of anti-cancer therapy and regenerative medicine. The controversies have been raised for their origin in different cell lines and effectiveness in thyroid pathologies including chemo- and radio-resistant thyroid cancer. Newer concepts like epithelial-mesenchymal transition have been investigated to define its role in metastatic activity. Literature discusses various methods to target these cells by interfering signaling pathways, destruction of niche and other factors which facilitate and sustain tumor growth.
Publish Date	2014-09-28 14:56
Citation	Bhatia P, Tsumagari K, Abd Elmageed ZY, Friedlander P, Buell JF, Kandil E. Stem cell biology in thyroid cancer: Insights for novel therapies. World J Stem Cells 2014; 6(5): 614-619
URL	http://www.wjgnet.com/1948-0210/full/v6/i5/614.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i5.614

Full Article (PDF)	WJSC-6-614.pdf
Full Article (Word)	WJSC-6-614.doc
Manuscript File	12830-Review.docx
Answering Reviewers	12830-Answering reviewers.pdf
Copyright License Agreement	12830-Copyright assignment.pdf
Peer-review Report	12830-Peer review(s).pdf
Scientific Misconduct Check	12830-CrossCheck.jpg
Scientific Editor Work List	12830-Scientific editor work list.pdf