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Articles Published Processes
9/28/2014 2:57:00 PM | Browse: 1201 | Download: 1277
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Received |
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2014-07-29 11:05 |
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Peer-Review Started |
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2014-07-30 13:32 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-09-01 09:40 |
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Revised |
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2014-09-05 03:58 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-09-17 14:02 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-09-17 14:29 |
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Articles in Press |
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2014-09-17 14:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-09-22 17:36 |
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Publish the Manuscript Online |
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2014-09-28 14:56 |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Roles of microRNA-140 in stem cell-associated early stage breast cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Benjamin Wolfson, Gabriel Eades and Qun Zhou |
| Funding Agency and Grant Number |
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| Corresponding Author |
Qun Zhou, Associate Professor, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, United States. qzhou@som.umaryland.edu |
| Key Words |
Breast cancer; Ductal carcinoma in situ; Invasive ductal carcinoma; Cancer stem cells; MicroRNA-140 |
| Core Tip |
MiR-140 is an important tumor suppressor. By inhibiting stem cell growth through interaction with the Wnt, SOX2 and SOX9 pathways, breast cancer initiation, progression and growth are reduced. miR-140 is progressively downregulated as breast cancer grade decreases, through both estrogen binding and differential methylation in the miR-140 promoter region. By targeting these mechanisms using epigenetic therapy miR-140 tumor suppressor signaling can be reactivated. |
| Publish Date |
2014-09-28 14:56 |
| Citation |
Wolfson B, Eades G, Zhou Q. Roles of microRNA-140 in stem cell-associated early stage breast cancer. World J Stem Cells 2014; 6(5): 591-597 |
| URL |
http://www.wjgnet.com/1948-0210/full/v6/i5/591.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v6.i5.591 |
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