Publication Name	World Journal of Stem Cells
Manuscript ID	12892
Country	United States

Received	2014-07-29 11:05
Peer-Review Started	2014-07-30 13:32
To Make the First Decision	2014-08-28 14:58
Return for Revision	2014-09-01 09:40
Revised	2014-09-05 03:58
Second Decision	2014-09-17 14:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-09-17 14:29
Articles in Press	2014-09-17 14:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-22 17:36
Publish the Manuscript Online	2014-09-28 14:56

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Minireviews
Article Title	Roles of microRNA-140 in stem cell-associated early stage breast cancer
Manuscript Source	Invited Manuscript
All Author List	Benjamin Wolfson, Gabriel Eades and Qun Zhou
Funding Agency and Grant Number
Corresponding Author	Qun Zhou, Associate Professor, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, United States. qzhou@som.umaryland.edu
Key Words	Breast cancer; Ductal carcinoma in situ; Invasive ductal carcinoma; Cancer stem cells; MicroRNA-140
Core Tip	MiR-140 is an important tumor suppressor. By inhibiting stem cell growth through interaction with the Wnt, SOX2 and SOX9 pathways, breast cancer initiation, progression and growth are reduced. miR-140 is progressively downregulated as breast cancer grade decreases, through both estrogen binding and differential methylation in the miR-140 promoter region. By targeting these mechanisms using epigenetic therapy miR-140 tumor suppressor signaling can be reactivated.
Publish Date	2014-09-28 14:56
Citation	Wolfson B, Eades G, Zhou Q. Roles of microRNA-140 in stem cell-associated early stage breast cancer. World J Stem Cells 2014; 6(5): 591-597
URL	http://www.wjgnet.com/1948-0210/full/v6/i5/591.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i5.591

Full Article (PDF)	WJSC-6-591.pdf
Full Article (Word)	WJSC-6-591.doc
Manuscript File	12892-Review.docx
Answering Reviewers	12892-Answering reviewers.pdf
Copyright License Agreement	12892-Copyright assignment.pdf
Peer-review Report	12892-Peer review(s).pdf
Scientific Misconduct Check	12892-CrossCheck.jpg
Scientific Editor Work List	12892-Scientific editor work list.pdf