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Articles Published Processes
2/11/2015 5:56:00 PM | Browse: 1172 | Download: 1285
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Received |
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2014-08-06 08:49 |
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Peer-Review Started |
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2014-08-06 14:37 |
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To Make the First Decision |
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2014-10-14 17:01 |
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Return for Revision |
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2014-10-15 17:15 |
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Revised |
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2014-10-25 01:51 |
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Second Decision |
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2014-11-11 10:11 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-11 10:34 |
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Articles in Press |
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2014-11-11 11:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-28 19:38 |
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Publish the Manuscript Online |
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2015-02-11 17:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Sirtuin 1 in rat orthotopic liver transplantation: An IGL-1 preservation solution approach
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Eirini Pantazi, Mohamed Amine Zaouali, Mohamed Bejaoui, Emma Folch-Puy, Hassen Ben Abdennebi, Ana Teresa Varela, Anabela Pinto Rolo, Carlos Marques Palmeira and Joan Roselló-Catafau |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fondo de Investigaciones Sanitarias |
FIS PI12/00519 |
| AGAUR |
2012FI_B00382(to Eirini Pantazi) |
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| Corresponding Author |
Joan Roselló-Catafau, Professor, Experimental Hepatic Ischemia, Reperfusion Unit, Institute of Biomedical Research of Barcelona, IIBB-CSIC, C/ Rosselló 161, 7th floor, 08036 Barcelona, Spain. jrcbam@iibb.csic.es |
| Key Words |
Sirtuin 1; Ischemia-reperfusion injury; Liver transplantation; IGL-1 preservation solution; Trimetazidine |
| Core Tip |
Sirtuin 1 (SIRT1) has been implicated in path?ways associated with ischemia-reperfusion injury (IRI), but its role in rat orthotopic liver transplantation has not yet been established. In our study, SIRT1 protein expression levels and activity increased when Institut Georges Lopez 1 (IGL-1) preservation solution was supplemented with trimetazidine, which was associated with less hepatic injury and mitochondrial damage. The increased deacetylation of FoxO1 by SIRT1 agreed with less oxidative stress and the activation of the autophagy pathway. These findings support the notion that SIRT1 up-regulation may be an effective strategy for reducing IRI and improving liver transplantation outcome. |
| Publish Date |
2015-02-11 17:56 |
| Citation |
Pantazi E, Zaouali MA, Bejaoui M, Folch-Puy E, Ben Abdennebi H, Varela AT, Rolo AP, Palmeira CM, Roselló-Catafau J. Sirtuin 1 in rat orthotopic liver transplantation: An IGL-1 preservation solution approach. World J Gastroenterol 2015; 21(6): 1765-1774 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i6/1765.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i6.1765 |
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