Publication Name	World Journal of Gastroenterology
Manuscript ID	13109
Country	United States

Received	2014-08-06 08:34
Peer-Review Started	2014-08-06 16:58
To Make the First Decision	2014-09-15 16:12
Return for Revision	2014-09-22 08:23
Revised	2014-10-18 13:51
Second Decision	2014-11-27 21:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-01 13:46
Articles in Press	2014-12-01 14:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-11 21:22
Publish the Manuscript Online	2015-03-09 15:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Case Report
Article Title	Pancreatic intraductal papillary mucinous neoplasm in a patient with Lynch syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Meghan R Flanagan, Arjun Jayaraj, Wei Xiong, Matthew M Yeh, Wendy H Raskind and Venu G Pillarisetty
Funding Agency and Grant Number	Funding Agency Grant Number University of Washington Department of Surgery, Seattle, WA
Corresponding Author	Venu G Pillarisetty, MD, Assistant Professor, Department of Surgery, University of Washington Medical Center, University of Washington, 1959 NE Pacific St. Box 356410, Seattle, WA 98195, United States. vgp@uw.edu
Key Words	Intraductal papillary mucinous neoplasm; Pancreatic cancer; Hereditary nonpolyposis colorectal cancer; Lynch syndrome; MSH2; Microsatellite instability
Core Tip	Intraductal papillary mucinous neoplasms (IPMN) are now recognized as important precursor lesions to pancreatic cancer. Although there have been reports linking pancreatic cancer and familial cancer syndromes, only one previous case report has described IPMN in a patient with Lynch syndrome. Our case is a main duct IPMN that contained only low-grade dysplasia and no microsatellite instability despite the presence of a germline MSH2 mutation. Mismatch repair (MMR) gene mutations may be involved in the neoplastic changes that drive the development of IPMN; however, changes in MMR function may not be detectable in the setting of low-grade neoplasia.
Publish Date	2015-03-09 15:58
Citation	Flanagan MR, Jayaraj A, Xiong W, Yeh MM, Raskind WH, Pillarisetty VG. Pancreatic intraductal papillary mucinous neoplasm in a patient with Lynch syndrome. World J Gastroenterol 2015; 21(9): 2820-2825
URL	http://www.wjgnet.com/1007-9327/full/v21/i9/2820.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i9.2820

Full Article (PDF)	WJG-21-2820.pdf
Full Article (Word)	WJG-21-2820.doc
Manuscript File	13109-Review.docx
Answering Reviewers	13109-Answering reviewers.pdf
Copyright License Agreement	13109-Copyright assignment.pdf
Peer-review Report	13109-Peer review(s).pdf
Scientific Misconduct Check	13109-CrossCheck.jpg
Scientific Editor Work List	13109-Scientific editor work list.pdf