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Articles Published Processes
2/11/2015 5:56:00 PM | Browse: 1428 | Download: 1452
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Received |
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2014-08-06 08:20 |
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Peer-Review Started |
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2014-08-06 13:42 |
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To Make the First Decision |
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2014-09-15 16:11 |
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Return for Revision |
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2014-09-22 08:24 |
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Revised |
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2014-10-03 23:11 |
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Second Decision |
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2014-11-10 16:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-19 09:26 |
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Articles in Press |
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2014-11-19 09:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-28 10:29 |
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Publish the Manuscript Online |
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2015-02-11 17:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease: Need for mucosal viral load measurement
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rachele Ciccocioppo, Francesca Racca, Stefania Paolucci, Giulia Campanini, Lodovica Pozzi, Elena Betti, Roberta Riboni, Alessandro Vanoli, Fausto Baldanti and Gino Roberto Corazza |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fondazione IRCCS Policlinico San Matteo |
8064409(in part) |
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| Corresponding Author |
Rachele Ciccocioppo, MD, Centre for the Study and Cure of Inflammatory Bowel Disease, Clinica Medica I, IRCCS San Matteo Hospital Foundation, University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy. rachele.ciccocioppo@unipv.it |
| Key Words |
Inflammatory bowel disease; quantitative real-time polymerase chain reaction; steroid therapy; refractory; viral infection |
| Core Tip |
This study investigated the presence of human Cytomegalovirus and Epstein-Barr virus (EBV) infection in patients with refractory and non-refractory inflammatory bowel disease (IBD). We identified qu?antitative real-time polymerase chain reaction assay of mucosal specimens as the best diagnostic technique. This allowed us to distinguish between viral colitis and infection through the identification of a cutoff value. All refractory IBD patients carried the highest mucosal viral loads, which correlated with the severity of mucosal damage and endoscopic activity. EBV infection was the most prevalent. Finally, steroid therapy was identified as a significant risk factor for viral colitis. |
| Publish Date |
2015-02-11 17:56 |
| Citation |
Ciccocioppo R, Racca F, Paolucci S, Campanini G, Pozzi L, Betti E, Riboni R, Vanoli A, Baldanti F, Corazza GR. human cytomegalovirus and epstein-barr virus infection in inflammatory bowel disease: need for mucosal viral load measurement. World J Gastroenterol 2015; 21(6): 1915-1926 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i6/1915.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i6.1915 |
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