Publication Name	World Journal of Gastroenterology
Manuscript ID	13115
Country	Italy

Received	2014-08-06 08:20
Peer-Review Started	2014-08-06 13:42
To Make the First Decision	2014-09-15 16:11
Return for Revision	2014-09-22 08:24
Revised	2014-10-03 23:11
Second Decision	2014-11-10 16:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-11-19 09:26
Articles in Press	2014-11-19 09:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-28 10:29
Publish the Manuscript Online	2015-02-11 17:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease: Need for mucosal viral load measurement
Manuscript Source	Invited Manuscript
All Author List	Rachele Ciccocioppo, Francesca Racca, Stefania Paolucci, Giulia Campanini, Lodovica Pozzi, Elena Betti, Roberta Riboni, Alessandro Vanoli, Fausto Baldanti and Gino Roberto Corazza
Funding Agency and Grant Number	Funding Agency Grant Number Fondazione IRCCS Policlinico San Matteo 8064409(in part)
Corresponding Author	Rachele Ciccocioppo, MD, Centre for the Study and Cure of Inflammatory Bowel Disease, Clinica Medica I, IRCCS San Matteo Hospital Foundation, University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy. rachele.ciccocioppo@unipv.it
Key Words	Inflammatory bowel disease; quantitative real-time polymerase chain reaction; steroid therapy; refractory; viral infection
Core Tip	This study investigated the presence of human Cytomegalovirus and Epstein-Barr virus (EBV) infection in patients with refractory and non-refractory inflammatory bowel disease (IBD). We identified qu?antitative real-time polymerase chain reaction assay of mucosal specimens as the best diagnostic technique. This allowed us to distinguish between viral colitis and infection through the identification of a cutoff value. All refractory IBD patients carried the highest mucosal viral loads, which correlated with the severity of mucosal damage and endoscopic activity. EBV infection was the most prevalent. Finally, steroid therapy was identified as a significant risk factor for viral colitis.
Publish Date	2015-02-11 17:56
Citation	Ciccocioppo R, Racca F, Paolucci S, Campanini G, Pozzi L, Betti E, Riboni R, Vanoli A, Baldanti F, Corazza GR. human cytomegalovirus and epstein-barr virus infection in inflammatory bowel disease: need for mucosal viral load measurement. World J Gastroenterol 2015; 21(6): 1915-1926
URL	http://www.wjgnet.com/1007-9327/full/v21/i6/1915.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i6.1915

Full Article (PDF)	WJG-21-1915.pdf
Full Article (Word)	WJG-21-1915.doc
Manuscript File	13115-Review.docx
Answering Reviewers	13115-Answering reviewers.pdf
Copyright License Agreement	13115-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	13115-Language certificate.pdf
Peer-review Report	13115-Peer review(s).pdf
Scientific Misconduct Check	13115-CrossCheck.jpg
Scientific Editor Work List	13115-Scientific editor work list.pdf