Publication Name	World Journal of Clinical Cases
Manuscript ID	13183
Country

Received	2014-08-11 19:41
Peer-Review Started	2014-08-14 14:28
To Make the First Decision	2014-09-16 10:56
Return for Revision	2014-09-19 11:13
Revised	2015-04-23 00:00
Second Decision	2015-05-08 17:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-05-18 17:17
Articles in Press	2015-05-18 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-07 18:52
Publish the Manuscript Online	2015-07-27 18:31

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Observational Study
Article Title	In vitro differentiation of human umbilical cord Wharton’s jelly mesenchymal stromal cells to insulin producing clusters
Manuscript Source	Invited Manuscript
All Author List	Seideh Masoomeh Nekoei, Negar Azarpira, Ladan Sadeghi and Sulmaz Kamalifar
Funding Agency and Grant Number
Corresponding Author	Negar Azarpira, MD, Transplant Research Center, Shiraz University of Medical Science, Zand Street, Shiraz 7193711351, Iran. negarazarpira@yahoo.com
Key Words	Mesenchymal stromal cells; Umbilical cord; Beta cell; Islet
Core Tip	Diabetes is a major chronic metabolic disorder in the world. Mesenchymal stromal cells (MSCs) has the ability to differentiate in to functional insulin producing cells.In this study, human Wharton’s jelly derived MSCs (The clusters expressed PDX1, NGN3, Glut2, and insulin. The cells became red color when stained with DTZ and the insulin secretion was confirmed Wharton’s jelly derived MSCs were differentiated to insulin producing clusters (IPCs). More efficient differentiation protocoles for generation of functional IPCs will be a potential new source for cell transplantation in diabetic patients.
Publish Date	2015-07-27 18:31
Citation	Nekoei SM, Azarpira N, Sadeghi L, Kamalifar S. In vitro differentiation of human umbilical cord Wharton’s jelly mesenchymal stromal cells to insulin producing clusters. World J Clin Cases 2015; 3(7): 640-649
URL	http://www.wjgnet.com/2307-8960/full/v3/i7/640.htm
DOI	http://dx.doi.org/10.12998/wjcc.v3.i7.640

Full Article (PDF)	WJCC-3-640.pdf
Full Article (Word)	WJCC-3-640.doc
Manuscript File	13183-Review.docx
Answering Reviewers	13183-Answering reviewers.pdf
Audio Core Tip	13183-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	13183-Conflict-of-interest statement.pdf
Copyright License Agreement	13183-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	13183-Institutional review board statement.pdf
Peer-review Report	13183-Peer-review(s).pdf
Scientific Misconduct Check	13183-Scientific misconduct check.pdf
Scientific Editor Work List	13183-Scientific editor work list.pdf