Publication Name	World Journal of Hepatology
Manuscript ID	13216
Country	Japan

Received	2014-08-12 17:19
Peer-Review Started	2014-08-12 18:49
To Make the First Decision	2014-08-28 14:55
Return for Revision	2014-09-01 10:47
Revised	2014-09-12 13:46
Second Decision	2014-10-29 18:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-29 18:59
Articles in Press	2014-10-29 18:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-08 13:04
Publish the Manuscript Online	2014-12-13 17:50

ISSN	1948-5182 (online)
Open Access
Copyright
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies
Manuscript Source	Invited Manuscript
All Author List	Masayoshi Takeuchi, Jun-ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Tadashi Ueda, Mikihiro Tsutsumi, Hideyuki Hyogo and Sho-ichi Yamagishi
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science (JSPS) KAKENHI Grant 19300254 (to Takeuchi M) Japan Society for the Promotion of Science (JSPS) KAKENHI Grant 22300264 (to Takeuchi M) Japan Society for the Promotion of Science (JSPS) KAKENHI Grant 25282029 (to Takeuchi M) Kanazawa Medical University SR2012-04 (to Tsutsumi M) Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Regional Innovation Strategy Support Program to Takeuchi M
Corresponding Author	Dr. Masayoshi Takeuchi, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Uchinada-machi, Ishikawa 920-0293, Japan. takeuchi@kanazawa-med.ac.jp
Key Words	Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Advanced glycation end-products; Toxic advanced glycation end-products; Receptor for advanced glycation end-products; Toxic advanced glycation end-products-receptor for advanced glycation end-products system; Diabetes mellitus; Cardiovascular disease; Dietary fructose; Dietary advanced glycation end-products
Core Tip	Toxic advanced glycation end-products (TAGE) synthesis is increased by non-alcoholic steatohepatitis (NASH), and patients with NASH exhibit significantly increased serum and hepatic TAGE concentrations. Interactions between TAGE and the receptor for advanced glycation end-products (RAGE) have been suggested to cause oxidative stress and increase the fibrogenic potential of cultured human hepatic stellate cells. Therefore, TAGE signaling via RAGE and the resultant synthesis of reactive oxygen species might play a role in the worsening of hepatic pathology seen in NASH. These observations led us to suggest that extracellular and intracellular TAGE are involved in the pathogenesis of NASH.
Publish Date	2014-12-13 17:50
Citation	Takeuchi M, Takino J, Sakasai-Sakai A, Takata T, Ueda T, Tsutsumi M, Hyogo H, Yamagishi S. Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies. World J Hepatol 2014; 6(12): 880-893
URL	http://www.wjgnet.com/1948-5182/full/v6/i12/880.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i12.880

Full Article (PDF)	WJH-6-880.pdf
Full Article (Word)	WJH-6-880.doc
Manuscript File	13216-Review.docx
Answering Reviewers	13216-Answering reviewers.pdf
Copyright License Agreement	13216-Copyright assignment.pdf
Peer-review Report	13216-Peer review(s).pdf
Scientific Misconduct Check	13216-CrossCheck.jpg
Scientific Editor Work List	13216-Scientific editor work list.pdf