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Articles Published Processes
2/11/2015 4:38:00 PM | Browse: 1049 | Download: 1382
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Received |
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2014-08-13 09:46 |
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Peer-Review Started |
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2014-08-13 19:43 |
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To Make the First Decision |
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2014-08-27 19:14 |
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Return for Revision |
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2014-08-29 17:09 |
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Revised |
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2014-09-05 10:34 |
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Second Decision |
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2014-10-15 07:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-10-15 08:03 |
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Articles in Press |
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2014-10-15 08:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-11-07 02:11 |
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Typeset the Manuscript |
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2015-02-02 14:40 |
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Publish the Manuscript Online |
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2015-02-11 16:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Negative impact of bone-marrow-derived mesenchymal stem cells on dextran sulfate sodium-induced colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Young-Sun Nam, Nayoun Kim, Keon-Il Im, Jung-Yeon Lim, Eun-Sol Lee and Seok-Goo Cho |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Korea Healthcare Technology R and D Project |
HI12C0193 (A120241) |
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| Corresponding Author |
Seok-Goo Cho, MD, PhD, Professor, Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary’s Hospital, Institute for Translational Research and Molecular Imaging, Laboratory of Immune Regulation, Convergent Research Consortium for Immunologic Disease, the Catholic University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701,
South Korea. chosg@catholic.ac.kr
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| Key Words |
Crohn’s disease; Dextran sulfate sodium; Inflammatory bowel disease; Mesenchymal stem cells; Ulcerative colitis |
| Core Tip |
We evaluated the effects of mesenchymal stem cells (MSCs) on inflammatory bowel disease (IBD). Although MSCs are considered useful therapeutic agents for treatment of IBD, their efficacy has not been immunologically confirmed. We found that MSCs did not exert significant effects and did not restore immune balance or influence levels of interleukins 6 and 10. Recent studies have shown that MSCs may be effective upon local infusion, or in combination with other agents. Therefore, new approaches toward regulation of the immunoregulatory properties of MSCs are required if such cells are to be used to alleviate IBD. |
| Publish Date |
2015-02-11 16:38 |
| Citation |
Nam YS, Kim N, Im KI, Lim JY, Lee ES, Cho SG. Negative impact of bone-marrow-derived mesenchymal stem cells on dextran sulfate sodium-induced colitis. World J Gastroenterol 2015; 21(7): 2030-2039 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i7/2030.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i7.2030 |
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