Publication Name	World Journal of Stem Cells
Manuscript ID	13241
Country	Japan

Received	2014-08-13 16:25
Peer-Review Started	2014-08-13 18:12
To Make the First Decision	2014-08-28 14:55
Return for Revision	2014-09-01 10:49
Revised	2014-09-11 20:10
Second Decision	2014-09-17 14:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-17 14:30
Articles in Press	2014-09-17 14:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-22 17:37
Publish the Manuscript Online	2014-09-28 14:56

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Review
Article Title	Connexin mutant embryonic stem cells and human diseases
Manuscript Source	Invited Manuscript
All Author List	Kiyomasa Nishii, Yosaburo Shibata and Yasushi Kobayashi
Funding Agency and Grant Number
Corresponding Author	Kiyomasa Nishii, MD, PhD, Department of Anatomy and Neurobiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. nishii@ndmc.ac.jp
Key Words	Embryonic stem cells; Induced pluripotent stem cells; Gap junction; Human diseases; Genetic models; Differentiation; Chimera
Core Tip	Numerous gap junction-encoding connexin (Cx) mutant mice have been established as models of human diseases. Although these analyses have facilitated current understanding of native Cx functions and the pathogenesis of related diseases, care must be taken when extrapolating findings from mice to humans, and vice versa, because there can be striking diversity in tissue organization and Cx expression patterns between these species. Recently, the use of human induced pluripotent stem cells (iPSCs) allowed further direct approaches for studying human diseases. According to the studies using mutant mouse embryonic stem cells, Cx mutant human iPSCs may become a useful model.
Publish Date	2014-09-28 14:56
Citation	Nishii K, Shibata Y, Kobayashi Y. Connexin mutant embryonic stem cells and human diseases. World J Stem Cells 2014; 6(5): 571-578
URL	http://www.wjgnet.com/1948-0210/full/v6/i5/571.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i5.571

Full Article (PDF)	WJSC-6-571.pdf
Full Article (Word)	WJSC-6-571.doc
Manuscript File	13241-Review.docx
Answering Reviewers	13241-Answering reviewers.pdf
Copyright License Agreement	13241-Copyright assignment.pdf
Peer-review Report	13241-Peer review(s).pdf
Scientific Misconduct Check	13241-CrossCheck.jpg
Scientific Editor Work List	13241-Scientific editor work list.pdf