Publication Name	World Journal of Psychiatry
Manuscript ID	13375
Country	United States

Received	2014-08-21 09:10
Peer-Review Started	2014-08-24 11:17
To Make the First Decision	2014-09-28 13:45
Return for Revision	2014-10-02 12:09
Revised	2014-12-02 01:47
Second Decision	2015-10-21 17:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-04 16:53
Articles in Press	2015-11-04 16:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-04 16:12
Publish the Manuscript Online	2015-12-18 19:53

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Psychiatry
Manuscript Type	Review
Article Title	Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches
Manuscript Source	Invited Manuscript
All Author List	Jeremy D Coplan, Cindy J Aaronson, Venkatesh Panthangi and Younsuk Kim
Funding Agency and Grant Number
Corresponding Author	Cindy J Aaronson, MSW, PhD, Assistant Clinical Professor of Psychiatry, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, United States. cindy.aaronson@mssm.edu
Key Words	Generalized anxiety disorder; Cognitive behavioral therapy; Treatment-resistant mood disorders; Bipolar disorder comorbid with anxiety; Augmentation strategies; Major depressive disorder
Core Tip	A comprehensive diagnostic assessment is a critical first step in treating patients with mixed anxiety and depression. Practitioners should be alert to the possibility that this may be a concealed bipolar disorder since misdiagnoses rates can be 70%. Treatment in the patient with uncomplicated non-substance-abusing unipolar disorder may be quite straight forward. However patients are in all likelihood treatment-resistant with probable bipolarity and substance abuse. In the latter instance, more complex regimen of medications with combinations of pharmacotherapy are required. Finally, a “stacking” approach, to cover the full spectrum of available receptors targeted by current pharmacotherapy regimens is recommended.
Publish Date	2015-12-18 19:53
Citation	Coplan JD, Aaronson CA, Panthangi V, Kim Y. Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches. World J Psychiatr 2015; 5(4): 366-378
URL	http://www.wjgnet.com/2220-3206/full/v5/i4/366.htm
DOI	http://dx.doi.org/10.5498/wjp.v5.i4.366

Full Article (PDF)	WJP-5-366.pdf
Full Article (Word)	WJP-5-366.doc
Manuscript File	13375-Review.docx
Answering Reviewers	13375-Answering reviewers.pdf
Audio Core Tip	13375-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	13375-Conflict-of-interest statement.pdf
Copyright License Agreement	13375-Copyright assignment.pdf
Peer-review Report	13375-Peer-review(s).pdf
Scientific Misconduct Check	13375-Scientific misconduct check.pdf
Scientific Editor Work List	13375-Scientific editor work list.pdf