Publication Name	World Journal of Hepatology
Manuscript ID	13606
Country	Germany

Received	2014-08-28 08:26
Peer-Review Started	2014-08-29 08:34
To Make the First Decision	2014-11-14 19:53
Return for Revision	2014-11-18 18:20
Revised	2014-11-30 02:40
Second Decision	2014-12-26 08:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-31 13:21
Articles in Press	2014-12-31 13:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-20 12:17
Publish the Manuscript Online	2015-03-31 15:58

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Spontaneous bacterial peritonitis: The clinical challenge of a leaky gut and a cirrhotic liver
Manuscript Source	Invited Manuscript
All Author List	Philipp Lutz, Hans Dieter Nischalke, Christian P Strassburg and Ulrich Spengler
Funding Agency and Grant Number
Corresponding Author	Dr. Philipp Lutz, Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, D-53129 Bonn, Germany. philipp.lutz@ukb.uni-bonn.de
Key Words	Ascites; Cirrhosis; Farnesoid X receptor; Liver; Nucleotide-binding oligomerization domain containing 2; Rifaximin; Prophylaxis; Spontaneous bacterial peritonitis; Toll-like receptor 2
Core Tip	Spontaneous bacterial peritonitis (SBP) is a frequent infection in patients with liver cirrhosis which is associated with a poor prognosis. Portal hypertension leads to translocation of intestinal bacteria which cannot be eliminated due to immune defects caused by liver cirrhosis and genetic predisposition. Empirical antibiotic treatment has become less effective because of wide-spread antibiotic resistance. This review summarises key features of SBP and points out how diagnosis, treatment and prophylaxis may be improved in the future in order to reduce mortality.
Publish Date	2015-03-31 15:58
Citation	Lutz P, Nischalke HD, Strassburg CP, Spengler U. Spontaneous bacterial peritonitis: The clinical challenge of a leaky gut and a cirrhotic liver. World J Hepatol 2015; 7(3): 304-314
URL	http://www.wjgnet.com/1948-5182/full/v7/i3/304.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i3.304

Full Article (PDF)	WJH-7-304.pdf
Full Article (Word)	WJH-7-304.doc
Manuscript File	13606-Review.docx
Answering Reviewers	13606-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13606-Conflict-of-interest statement.pdf
Copyright License Agreement	13606-Copyright assignment.pdf
Peer-review Report	13606-Peer review(s).pdf
Scientific Misconduct Check	13606-CrossCheck.jpg
Scientific Editor Work List	13606-Scientific editor work list.pdf