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Articles Published Processes
12/2/2015 12:01:00 PM | Browse: 1600 | Download: 2128
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Received |
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2014-08-28 08:12 |
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Peer-Review Started |
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2014-08-28 19:44 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-09-19 17:39 |
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Revised |
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2014-11-27 00:00 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-11-21 08:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-12-01 14:08 |
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Articles in Press |
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2014-12-01 14:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-03-23 11:17 |
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Publish the Manuscript Online |
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2015-03-31 15:58 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Angiogenesis and liver fibrosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Gülsüm Özlem Elpek |
| Funding Agency and Grant Number |
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| Corresponding Author |
Gülsüm Özlem Elpek, MD, Professor, Department of Pathology, Akdeniz University Medical School, Dumlupınar Bulvarı, 07070 Antalya,
Turkey. elpek@akdeniz.edu.tr
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| Key Words |
Liver fibrosis; Angiogenesis; Cirrhosis; Fibrogenesis; Hepatic stellate cells; Vascular endothelial growth factor; Hypoxia; Chronic liver disease |
| Core Tip |
Hepatic angiogenesis is closely associated with the progression of fibrosis in chronic liver diseases (CLDs). Recent evidences demonstrated that blocking angiogenesis means also prevention of fibrosis progre-ssion. Hypoxia plays a crucial role in eliciting angiogenesis together with hepatic stellate cells being the most prominent sources of vascular endothelial growth factor and Angiopoietin-1. Adipokines, endoplasmic reticulum stress and related unfolded protein response; neuropilins; might be future therapeutical target in the progression of fibrosis in CLDs. Moreover studies on non-alcoholic steatohepatits demonstrated that of angiotensin and renin inhibitors could be effectively used as a new treat-ment strategy against angiogenesis in the prevention of fibrosis in CLDs.
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| Publish Date |
2015-03-31 15:58 |
| Citation |
Elpek GO. Angiogenesis and liver fibrosis. World J Hepatol 2015; 7(3): 377-391 |
| URL |
http://www.wjgnet.com/1948-5182/full/v7/i3/377.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v7.i3.377 |
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