Publication Name	World Journal of Hepatology
Manuscript ID	13615
Country	Türkiye

Received	2014-08-28 08:12
Peer-Review Started	2014-08-28 19:44
To Make the First Decision	2014-09-16 10:53
Return for Revision	2014-09-19 17:39
Revised	2014-11-27 00:00
Second Decision	2014-11-21 08:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-01 14:08
Articles in Press	2014-12-01 14:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-23 11:17
Publish the Manuscript Online	2015-03-31 15:58

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Angiogenesis and liver fibrosis
Manuscript Source	Invited Manuscript
All Author List	Gülsüm Özlem Elpek
Funding Agency and Grant Number
Corresponding Author	Gülsüm Özlem Elpek, MD, Professor, Department of Pathology, Akdeniz University Medical School, Dumlupınar Bulvarı, 07070 Antalya, Turkey. elpek@akdeniz.edu.tr
Key Words	Liver fibrosis; Angiogenesis; Cirrhosis; Fibrogenesis; Hepatic stellate cells; Vascular endothelial growth factor; Hypoxia; Chronic liver disease
Core Tip	Hepatic angiogenesis is closely associated with the progression of fibrosis in chronic liver diseases (CLDs). Recent evidences demonstrated that blocking angiogenesis means also prevention of fibrosis progre-ssion. Hypoxia plays a crucial role in eliciting angiogenesis together with hepatic stellate cells being the most prominent sources of vascular endothelial growth factor and Angiopoietin-1. Adipokines, endoplasmic reticulum stress and related unfolded protein response; neuropilins; might be future therapeutical target in the progression of fibrosis in CLDs. Moreover studies on non-alcoholic steatohepatits demonstrated that of angiotensin and renin inhibitors could be effectively used as a new treat-ment strategy against angiogenesis in the prevention of fibrosis in CLDs.
Publish Date	2015-03-31 15:58
Citation	Elpek GO. Angiogenesis and liver fibrosis. World J Hepatol 2015; 7(3): 377-391
URL	http://www.wjgnet.com/1948-5182/full/v7/i3/377.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i3.377

Full Article (PDF)	WJH-7-377.pdf
Full Article (Word)	WJH-7-377.doc
Manuscript File	13615-Review.docx
Answering Reviewers	13615-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13615-Conflict of interest.pdf
Copyright License Agreement	13615-Copyright assignment.pdf
Peer-review Report	13615-Peer review(s).pdf
Scientific Misconduct Check	13615-CrossCheck.jpg
Scientific Editor Work List	13615-Scientific editor work list.pdf