| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Assessment of clinical and radiological response to sorafenib in hepatocellular carcinoma patients
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Rodolfo Sacco, Valeria Mismas, Antonio Romano, Marco Bertini, Michele Bertoni, Graziana Federici, Salvatore Metrangolo, Giuseppe Parisi, Emanuele Tumino, Giampaolo Bresci, Luca Giacomelli, Sara Marceglia and Irene Bargellini |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Rodolfo Sacco, MD, PhD, Dipartimento di Gastroenterologia-UO Gastroenterologia e Malattie del Ricambio, Azienda Ospedaliero Universitaria Pisana, Via Paradisa 2, 56124 Pisa, Italy. r.sacco@ao-pisa.toscana.it
|
| Key Words |
Hepatocellular carcinoma; Sorafenib; Response Evaluation Criteria in Solid Tumors; Perfusion computed tomography; Dynamic Contrast-Enhanced-UltraSound; Volumetric assessment |
| Core Tip |
The development of new treatment options for hepatocellular carcinoma has changed not only the way in which cancer is treated, but also how it is diagnosed and especially the assessment of tumor response. The traditional radiologic methods, which are mainly based on the evaluation of variations in tumor size, are considered insufficiently sensitive and unreliable in determining tumor progression when targeted therapies like sorafenib are involved. New assessment tools trying to combine morphological and vascular functional data to obtain an accurate measurement of tumor characteristics such as volume, density or vascularization, showed positive results in assessing patient’s response to therapy.
|
| Publish Date |
2015-01-10 16:31 |
| Citation |
Sacco R, Mismas V, Romano A, Bertini M, Bertoni M, Federici G, Metrangolo S, Parisi G, Tumino E, Bresci G, Giacomelli L, Marceglia S, Bargellini I. Assessment of clinical and radiological response to sorafenib in hepatocellular carcinoma patients. World J Hepatol 2015; 7(1): 33-39 |
| URL |
http://www.wjgnet.com/1948-5182/full/v7/i1/33.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v7.i1.33 |
