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Articles Published Processes
4/20/2015 9:13:00 AM | Browse: 872 | Download: 1106
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Received |
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2014-08-29 09:23 |
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Peer-Review Started |
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2014-08-30 11:35 |
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To Make the First Decision |
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2014-11-27 12:19 |
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Return for Revision |
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2014-12-02 14:30 |
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Revised |
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2014-12-09 04:02 |
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Second Decision |
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2014-12-29 18:26 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-01-12 14:22 |
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Articles in Press |
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2015-01-12 14:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-04-07 16:50 |
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Publish the Manuscript Online |
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2015-04-20 09:13 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Obstetrics & Gynecology |
| Manuscript Type |
Minireviews |
| Article Title |
Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rinat Gabbay-Benziv, E Albert Reece, Fang Wang and Peixin Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH |
R01DK083243 |
| NIH |
R01DK101972 |
| NIH |
DK095380 (to Yang P) |
| NIH |
R01DK103024 (to Yang P and Reece EA) |
| Basic Science Award |
1-13-BS-220 |
| American Diabetes Association |
to Yang P |
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| Corresponding Author |
Peixin Yang, PhD, Department of Obstetrics, Gynaecology and Reproductive Sciences, University of Maryland School of Medicine, BRB11-039, 655 W. Baltimore Street, Baltimore, MD 21201,
United States. pyang@fpi.umaryland.edu
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| Key Words |
Pregestational diabetes; Birth defects; Glycemic threshold; Diabetic embryopathy; Range of defects |
| Core Tip |
Pregestational diabetes is a rising problem with gravid impact on adverse pregnancy outcomes. This review concentrates on diabetes-induced birth defects and the underlying mechanism of diabetic embryopathy derived from animal studies. The main defects associated with pregestational diabetes are in the cardiovascular and central nervous systems, and are linearly related to maternal glycemic control. Animal studies reveal oxidative stress and stress kinase signalling-induced apoptosis as key factors in pathogenesis. However, many questions remain unanswered, and the rate of congenital defects in human diabetic pregnancies is still high. The cause of diabetic embryopathy warrants further investigations.
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| Publish Date |
2015-04-20 09:13 |
| Citation |
Gabbay-Benziv R, Reece EA, Wang F, Yang P. Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis. World J Diabetes 2015; 6(3): 481-488 |
| URL |
http://www.wjgnet.com/1948-9358/full/v6/i3/481.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v6.i3.481 |
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