Publication Name	World Journal of Stem Cells
Manuscript ID	13720
Country	United States

Received	2014-08-29 09:31
Peer-Review Started	2014-08-29 17:00
To Make the First Decision	2014-09-04 09:26
Return for Revision	2014-09-04 10:15
Revised	2014-09-10 04:52
Second Decision	2014-09-17 09:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-09-17 09:52
Articles in Press	2014-09-17 09:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-22 17:35
Publish the Manuscript Online	2014-09-28 14:56

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Review
Article Title	Histone modifications: Targeting head and neck cancer stem cells
Manuscript Source	Invited Manuscript
All Author List	John Le, Cristiane H Squarize and Rogerio M Castilho
Funding Agency and Grant Number	Funding Agency Grant Number University of Michigan, School of Dentistry startup
Corresponding Author	Rogerio M Castilho, DDS, MS, PhD, Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan, 1011 N University Ave, Room 3323B, Ann Arbor, MI 48109-1078, United States. rcastilh@umich.edu
Key Words	Head and neck squamous cell carcinoma; Chromatin remodeling; Histone deacteylases inhibitor; Histone acetylation; Cancer initiating cell; Epigenetic target; Epigenetic marker; Oral squamous cell carcinoma; Tumor resistance
Core Tip	Stem cells are long-lived, therefore their genome is subject to more stress from genetic mutations and epigenetic factors than their short-lived, differentiated progeny. Recent evidence strongly indicates that a subpopulation of tumor initiating cells, termed “cancer stem cells”, play a fundamental role in tumor heterogeneity, growth, and preservation. Cancer stem cells behavior is influenced by epigenetic events comprised primarily of DNA methylation and histone modifications that dynamically regulate gene expression and silencing.
Publish Date	2014-09-28 14:56
Citation	Le JM, Squarize CH, Castilho RM. Histone modifications: Targeting head and neck cancer stem cells. World J Stem Cells 2014; 6(5): 511-525
URL	http://www.wjgnet.com/1948-0210/full/v6/i5/511.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i5.511

Full Article (PDF)	WJSC-6-511.pdf
Full Article (Word)	WJSC-6-511.doc
Manuscript File	13720-Review.docx
Answering Reviewers	13720-Answering reviewers.pdf
Copyright License Agreement	13720-Copyright assignments.pdf
Peer-review Report	13720-Peer review(s).pdf
Scientific Misconduct Check	13720-CrossCheck.jpg
Scientific Editor Work List	13720-Scientific editor work list.pdf