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3/12/2015 7:39:00 PM | Browse: 1245 | Download: 1614
Publication Name World Journal of Pharmacology
Manuscript ID 13758
Country/Territory Finland
Received
2014-09-01 09:43
Peer-Review Started
2014-09-03 11:00
To Make the First Decision
2014-10-14 17:33
Return for Revision
2014-10-20 08:14
Revised
2014-11-18 01:31
Second Decision
2015-01-09 19:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-01-19 13:27
Articles in Press
2015-01-19 13:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-03-09 18:32
Publish the Manuscript Online
2015-03-12 19:39
ISSN 2220-3192 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Importance of microenvironment in preclinical models of breast and prostate cancer
Manuscript Source Invited Manuscript
All Author List Maija Valta, Katja Fagerlund, Mari Suominen, Jussi Halleen and Johanna Tuomela
Funding Agency and Grant Number
Funding Agency Grant Number
Eurostars program of Eureka
Corresponding Author Johanna Tuomela, PhD, Adjunct Professor, Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland. jomitu@utu.fi
Key Words Tumor microenvironment; Breast cancer; Prostate cancer; Preclinical; Efficacy
Core Tip It is today a recognized major problem in cancer drug development that the vast majority of drugs entering clinical trials fail to reach the market due to poor efficacy. One important reason for this is the wide use of subcutaneous xenograft models that are cheap, fast and easy to perform, but lack tumor microenvironment. Concentrating on breast and prostate cancer, we explain why the presence of tumor microenvironment is important, and describe different types of preclinical efficacy models that incorporate tumor microenvironment. We state the importance of using these models to reduce the high failure rates in clinical trials.
Publish Date 2015-03-12 19:39
Citation Valta M, Fagerlund K, Suominen M, Halleen J, Tuomela J. Importance of microenvironment in preclinical models of breast and prostate cancer. World J Pharmacol 2015; 4(1): 47-57
URL http://www.wjgnet.com/2220-3192/full/v4/i1/47.htm
DOI http://dx.doi.org/10.5497/wjp.v4.i1.47
Full Article (PDF) WJP-4-47.pdf
Full Article (Word) WJP-4-47.doc
Manuscript File 13758-Review.docx
Answering Reviewers 13758-Conflict of interest statement.pdf
Conflict-of-Interest Disclosure Form 13758-Conflict of interest statement.pdf
Copyright License Agreement 13758-Copyright assignment.pdf
Peer-review Report 13758-Peer-review(s).pdf
Scientific Misconduct Check 13758-CorssCheck.jpg
Scientific Editor Work List 13758-Scientific editor work list.pdf