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Articles Published Processes
4/30/2015 2:11:00 PM | Browse: 1108 | Download: 1635
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Received |
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2014-09-03 09:26 |
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Peer-Review Started |
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2014-09-03 13:20 |
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To Make the First Decision |
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2014-09-27 16:37 |
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Return for Revision |
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2014-09-30 15:11 |
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Revised |
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2014-10-11 11:06 |
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Second Decision |
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2014-11-27 21:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-12-01 13:48 |
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Articles in Press |
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2014-12-01 14:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-12-18 04:35 |
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Typeset the Manuscript |
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2015-04-07 11:14 |
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Publish the Manuscript Online |
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2015-04-20 15:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Integrin antagonists are effective and safe for Crohn disease treatment: A meta-analysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Song Ge and Jian-Gao Fan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81200279 |
| Medical-Engineering (Science) cross-Research Fund of Shanghai Jiao Tong University |
YG2011MS29 |
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| Corresponding Author |
Jian-Gao Fan, MD, Department of Gastroenterology, Shanghai Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. xinhuafjg@126.com |
| Key Words |
Crohn disease; Efficacy; Integrin antagonist; Meta-analysis; Safety |
| Core Tip |
Α-integrin antagonists were used to treat Crohn disease, but their efficacy and safety are not certain yet. We performed this systematic review and meta-analysis to evaluate the efficacy and safety of integrin antagonists including natalizumab and vedolizumab in Crohn disease. During 6-12 wk treatment, integrin antagonists can increase the rate of clinical response and remission. And no significant difference was found between integrin antagonists and placebo treatments regarding their adverse reaction and serious adverse reaction. These results have proven the efficacy and safety of integrin antagonists for Crohn disease treatment. |
| Publish Date |
2015-04-20 15:10 |
| Citation |
Ge WS, Fan JG. Integrin antagonists are effective and safe for Crohn’s disease: A meta-analysis. World J Gastroenterol 2015; 21(15): 4744-4749 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i15/4744.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i15.4744 |
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