Publication Name	World Journal of Gastroenterology
Manuscript ID	13991
Country	Türkiye

Received	2014-09-12 08:44
Peer-Review Started	2014-09-12 20:24
To Make the First Decision	2014-10-29 15:02
Return for Revision	2014-11-03 10:17
Revised	2014-12-01 19:06
Second Decision	2014-12-26 13:44
Accepted by Journal Editor-in-Chief	2014-12-27 18:42
Accepted by Executive Editor-in-Chief	2015-01-16 17:31
Articles in Press	2015-01-16 18:20
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-01-21 22:01
Typeset the Manuscript	2015-03-13 18:35
Publish the Manuscript Online	2015-03-30 14:23

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Helicobacter pylori and serum kynurenine-tryptophan ratio in patients with colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Ayse Basak Engin, Bensu Karahalil, Ali Esat Karakaya and Atilla Engin
Funding Agency and Grant Number
Corresponding Author	Ayse Basak Engin, PhD, Department of Toxicology, Faculty of Pharmacy, Gazi University, TR 06330 Hipodrom, Ankara, Turkey. abengin@gmail.com
Key Words	Colorectal cancer; Kynurenine/tryptophan; Immune tolerance; Helicobacter pylori; Oxidative stress
Core Tip	Persistent inflammation of the stomach induced by Helicobacter pylori (H. pylori) can have consequences on the rest of the body. Despite the vigorous innate and adaptive immune response against the bacterium, H. pylori escape and evade host responses by a variety of mechanisms. Low tryptophan levels and increased concentrations of its degradation product, kynurenine, may be directly involved in diminished T-cell responsiveness to antigenic stimulation in cancer. H. pylori seropositive colorectal cancer patients with significantly higher kynurenine/tryptophan and reduced nitric oxide suggested that H. pylori might support immune tolerance leading to cancer development, even in patients without an apparent upper gastrointestinal tract disease.
Publish Date	2015-03-30 14:23
Citation	Engin AB, Karahalil B, Karakaya AE, Engin A. Helicobacter pylori and serum kynurenine-tryptophan ratio in patients with colorectal cancer. World J Gastroenterol 2015; 21(12): 3636-3643
URL	http://www.wjgnet.com/1007-9327/full/v21/i12/3636.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i12.3636

Full Article (PDF)	WJG-21-3636.pdf
Full Article (Word)	WJG-21-3636.doc
Manuscript File	13991-Review.doc
Answering Reviewers	13991-Answering reviewers.pdf
Biostatistics Review Certificate	13991-Biostatistics statement.pdf
Clinical Trial Registration Statement	13991-Clinical trial registration.pdf
Conflict-of-Interest Disclosure Form	13991-Conflict-of-interest statement.pdf
Copyright License Agreement	13991-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	13991-Clinical trial registration.pdf
Institutional Review Board Approval Form or Document	13991-Institutional Review Board (IRB) statement.pdf
Peer-review Report	13991-Peer-review(s).pdf
Scientific Misconduct Check	13991-CorssCheck.jpg
Scientific Editor Work List	13991-Scientific editor work list.pdf