Publication Name	World Journal of Dermatology
Manuscript ID	14147
Country	United Kingdom

Received	2014-09-22 09:39
Peer-Review Started	2014-09-22 16:38
First Decision by Editorial Office Director
Return for Revision	2014-11-01 18:19
Revised	2014-11-29 17:26
Publication Fee Transferred
Second Decision by Editor	2014-12-11 17:25
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-12-17 16:13
Articles in Press	2014-12-17 16:13
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-16 13:49
Publish the Manuscript Online	2015-01-20 11:05

ISSN	2218-6190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Dermatology
Manuscript Type	Review
Article Title	From the outside-in: Epidermal targeting as a paradigm for atopic disease therapy
Manuscript Source	Invited Manuscript
All Author List	Rachel MC Gillespie and Sara J Brown
Funding Agency and Grant Number
Corresponding Author	Sara J Brown, MD, Dermatology and Genetic Medicine, College of Medicine, Dentistry and Nursing, University of Dundee, James Arrott Drive, Ninewells Hospital and Medical School, DD1 9SYD undee, United Kingdom. s.j.brown@dundee.ac.uk
Key Words	Atopic dermatitis; Eczema; Filaggrin; Skin barrier; Kallikrein; Thymic stromal lymphopoietin; Allergic sensitization; Atopic march
Core Tip	Atopic diseases [including atopic dermatitis (AD), allergic rhinitis and asthma] are characterised by Th2-type inflammation. Research over the past decade has highlighted a crucial role for primary skin barrier impairment in the pathogenesis of AD and associated atopic phenotypes. Notably, the epidermal protein, filaggrin, epidermal serine proteases, and the pro-Th2 cytokine thymic stromal lymphopoietin, have been implicated in disease development. We review the evidence upholding a role for epidermal defects in the initiation of skin inflammation in AD, allergic sensitization and pathogenesis of the “atopic march”, and discuss the clinical implications of these findings.
Publish Date	2015-01-20 11:05
Citation	Gillespie RMC, Brown SJ. From the outside-in: Epidermal targeting as a paradigm for atopic disease therapy. World J Dermatol 2015; 4(1): 16-32
URL	http://www.wjgnet.com/2218-6190/full/v4/i1/16.htm
DOI	http://dx.doi.org/10.5314/wjd.v4.i1.16

Full Article (PDF)	WJD-4-1.pdf
Full Article (Word)	WJD-4-1.doc
Manuscript File	14147-Review.docx
Answering Reviewers	14147-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14147-Conflict-of-interest statement.pdf
Copyright License Agreement	14147-Copyright assignment.pdf
Peer-review Report	14147-Peer review(s).pdf
Scientific Editor Work List	14147-Scientific editor work list.pdf