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Articles Published Processes
4/27/2015 4:29:00 PM | Browse: 1000 | Download: 1395
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Received |
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2014-09-23 14:41 |
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Peer-Review Started |
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2014-09-25 08:45 |
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To Make the First Decision |
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2014-10-14 16:44 |
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Return for Revision |
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2014-10-20 13:28 |
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Revised |
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2014-10-30 12:07 |
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Second Decision |
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2015-01-12 14:00 |
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Accepted by Journal Editor-in-Chief |
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2015-01-14 09:26 |
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Accepted by Executive Editor-in-Chief |
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2015-01-16 18:10 |
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Articles in Press |
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2015-01-16 18:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-04-10 18:10 |
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Publish the Manuscript Online |
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2015-04-27 16:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Evidence-Based Medicine |
| Article Title |
Hepatitis B virus preS1 deletion is related to viral replication increase and disease progression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Seoung-Ae Lee, Ki-Jeong Kim, Hong Kim, Won-Hyuk Choi, Yu-Sub Won and Bum-Joon Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea |
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| Korean government (Ministry of Education, Science, and Technology) |
2013-005810 |
| Foundation of Seoul National University Hospital |
0320140140 |
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| Corresponding Author |
Bum-Joon Kim, Professor, Department of Biomedical Sciences, Microbiology and Immunology, and Liver Research Institute, Seoul National University College of Medicine, Seoul 110-799, South Korea. kbumjoon@snu.ac.kr |
| Key Words |
Hepatitis B virus; PreS1 start codon deletion; Hepatitis B virus e antigen; Hepatocellular carcinoma; Genotype C |
| Core Tip |
Our data indicate that the hepatitis B virus (HBV) genotype C preS1 deletion might significantly contribute to disease progression in chronic HBV subjects through an extended duration of Hepatitis B virus e antigen seropositive status and increased HBV replication. This study provides novel insight into the greater infectivity and virulence of genotype C compared with other genotypes. In addition, the fluorescence resonance energy transfer-based real-time polymerase chain reaction used to detect the preS1 deletion shows promise for the earlier prediction of the risk of liver disease progression in chronic HBV subjects. |
| Publish Date |
2015-04-27 16:22 |
| Citation |
Lee SA, Kim KJ, Kim H, Choi WH, Won YS, Kim BJ. Hepatitis B virus preS1 deletion is related to viral replication increase and disease progression. World J Gastroenterol 2015; 21(16): 5039-5048 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i16/5039.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i16.5039 |
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