Publication Name	World Journal of Anesthesiology
Manuscript ID	1419
Country	Belgium

Received	2012-12-09 17:16
Peer-Review Started	2012-12-10 17:12
To Make the First Decision	2012-12-19 13:06
Return for Revision	2012-12-20 17:31
Revised
Second Decision	2013-04-15 16:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-04-16 07:53
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-02 10:24
Publish the Manuscript Online	2013-05-09 16:33

ISSN	2218-6182 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Anesthesiology
Manuscript Type	Diagnostic Advances
Article Title	Clinical pharmacology of intravenous paracetamol in perinatal medicine
Manuscript Source	Invited Manuscript
All Author List	Karel Allegaert
Funding Agency and Grant Number	Funding Agency Grant Number The Fund for Scientific Research, Flanders, Fundamental Clinical Investigatorship 1800209N
Corresponding Author	Karel Allegaert, MD, PhD, Neonatal Intensive Care Unit, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium. karel.allegaert@uzleuven.be
Key Words	Pregnancy; Newborn; Intravenous paracetamol; Pharmacokinetics
Core Tip	Although urgently needed to further improve patient tailored pharmacotherapy, data on the clinical pharmacology in pregnant women and young infants are limited, even for commonly used drugs like paracetamol. We summarize the available observations on both pharmacokinetics and pharmacodynamics of intravenous paracetamol in pregnant women and early infancy to illustrate the relevance of subpopulation specific observations. This includes differences in metabolic routes of elimination, in (side) effects (e.g., analgesia, hypotension, atopy) and in potential indications (patent ductus arteriosus).
Publish Date	2013-05-09 16:33
Citation	Allegaert K. Clinical pharmacology of intravenous paracetamol in perinatal medicine. World J Anesthesiol 2013; 2(1): 1-7
URL	http://www.wjgnet.com/2218-6182/full/v2/i1/1.htm
DOI	http://dx.doi.org/10.5313/wja.v2.i1.1

Full Article (PDF)	WJA-2-1.pdf
Manuscript File	1419-Review.docx
Answering Reviewers	1419-Answering reviewers.pdf
Copyright License Agreement	1419-Copyright assignment.pdf
Peer-review Report	1419-Peer review.pdf
Scientific Editor Work List	1419-Scientific editor work list.doc