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Articles Published Processes
4/15/2015 11:01:00 AM | Browse: 950 | Download: 1781
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Received |
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2014-09-27 12:27 |
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Peer-Review Started |
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2014-09-29 15:50 |
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To Make the First Decision |
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2014-10-29 14:22 |
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Return for Revision |
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2014-11-13 10:28 |
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Revised |
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2014-12-16 19:49 |
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Second Decision |
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2015-01-08 13:12 |
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Accepted by Journal Editor-in-Chief |
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2015-01-10 14:22 |
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Accepted by Executive Editor-in-Chief |
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2015-01-16 17:32 |
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Articles in Press |
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2015-01-16 18:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-03-02 19:53 |
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Typeset the Manuscript |
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2015-03-26 16:06 |
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Publish the Manuscript Online |
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2015-04-15 11:01 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Early activated hepatic stellate cell-derived molecules reverse acute hepatic injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Ju Chang, Lu-Jun Song, Tuo Yi, Kun-Tang Shen, Hong-Shan Wang, Xiao-Dong Gao, Min Li, Jian-Min Xu, Wei-Xin Niu and Xin-Yu Qin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Doctoral Fund of the Ministry of Education |
2013007110041 |
| Young Investigator Funding of Zhongshan Hospital |
2014ZSQN37 |
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| Corresponding Author |
Xin-Yu Qin, MD, Department of General Surgery, Zhongshan Hospital, Institute of General Surgery, Fudan University, No. 220 Handan Road, Shanghai 200032, China. qin.xinyu@zs-hospital.sh.cn |
| Key Words |
Hepatic stellate cells; Acute liver injury; Initiation and perpetuation |
| Core Tip |
In this study, we isolated hepatic stellate cells (HSCs) from mice by in situ perfusion of the liver and created primary and secondary cultures in plastic tissue culture dishes. Then, we observed different morphologies and phenotypes between initiation HSCs and perpetuation HSCs and described the first use of molecules secreted from HSCs in acetaminophen-induced acute liver injury. Initiation HSC-derived molecules showed hepatocyte-protective effects. Our findings provide novel insight into the mechanisms of HSCs in liver injury therapy. Whether the potential value of initiation HSC-derived molecular therapy is derived from the effect of a single cytokine or a combination of cytokines should be explored in future. |
| Publish Date |
2015-04-15 11:01 |
| Citation |
Chang WJ, Song LJ, Yi T, Shen KT, Wang HS, Gao XD, Li M, Xu JM, Niu WX, Qin XY. Early activated hepatic stellate cell-derived molecules reverse acute hepatic injury. World J Gastroenterol 2015; 21(14): 4184-4194 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i14/4184.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i14.4184 |
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