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12/25/2014 6:07:00 PM | Browse: 621 | Download: 735
Publication Name World Journal of Neurology
Manuscript ID 14348
Country of Manuscript Source United Kingdom
Received
2014-09-29 08:17
Peer-Review Started
2014-09-29 11:12
To Make the First Decision
2014-10-14 17:26
Return for Revision
2014-10-20 08:08
Revised
2014-11-11 16:32
Second Decision
2014-11-26 11:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-12-01 13:47
Articles in Press
2014-12-01 13:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-12-20 14:02
Publish the Manuscript Online
2014-12-25 18:06
ISSN 2218-6212 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Neurosciences
Manuscript Type Review
Article Title Cerebral ageing-the role of insulin and insulin-like growth factor signalling: A review
Manuscript Source Invited Manuscript
All Author List Georgia Romain and Jolanta Opacka-Juffry
Funding Agency and Grant Number
Corresponding author Jolanta Opacka-Juffry, Professor, Department of Life Sciences, University of Roehampton, SW15 4JD London, United Kingdom. j.opacka-juffry@roehampton.ac.uk
Keywords Brain; Insulin; Insulin receptor; Insulin-like growth factor; Longevity; Alzheimer’s; Diabetes mellitus; Inflammation
Core Tip Age itself is a major risk factor for the develop-ment of age-related cognitive decline, Alzheimer’s and cerebrovascular diseases. Increased life expectancy necessitates the need to understand the processes that underlie successful vs pathological brain ageing in order to develop early interventions which may assist in delaying if not reversing the detrimental effects of brain ageing. This review focuses on the signalling system of insulin and insulin-like growth factor-1 (IIS) and its roles in cerebral ageing; it highlights some conflicting literature opinions and incomplete understandings of the roles and mechanisms of the IIS system.
Publish Date 2014-12-25 18:06
Citation Romain G, Opacka-Juffry J. Cerebral ageing-the role of insulin and insulin-like growth factor signalling: A review. World J Neurol 2014; 4(3): 12-22
Url http://www.wjgnet.com/2218-6212/full/v4/i3/12.htm
DOI http://dx.doi.org/10.5316/wjn.v4.i3.12
Full Article (PDF) WJN-4-12.pdf
Full Article (Word) WJN-4-12.doc
Manuscript File 14348-Review.docx
Answering Reviewers 14348-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 14348-Conflict-of-interest.pdf
Copyright License Agreement 14348-Copyright assignment.pdf
Peer-review Report 14348-Peer review(s).pdf
Scientific Misconduct Check 14348-CorssCheck.jpg
Scientific Editor Work List 14348-Scientific editor work list.pdf