Publication Name	World Journal of Gastroenterology
Manuscript ID	14413
Country	Spain

Received	2014-10-03 12:48
Peer-Review Started	2014-10-03 21:45
To Make the First Decision	2014-10-29 14:55
Return for Revision	2014-11-03 14:31
Revised	2014-11-18 04:54
Second Decision	2015-01-14 08:48
Accepted by Journal Editor-in-Chief	2015-01-14 15:18
Accepted by Executive Editor-in-Chief	2015-01-16 18:02
Articles in Press	2015-01-16 18:22
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-02-22 23:34
Typeset the Manuscript	2015-03-08 20:00
Publish the Manuscript Online	2015-03-19 16:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Observational Study
Article Title	Recurrent anal fistulae: Limited surgery supported by stem cells
Manuscript Source	Invited Manuscript
All Author List	Damian Garcia-Olmo, Hector Guadalajara, Ines Rubio-Perez, Maria Dolores Herreros, Paloma de-la-Quintana and Mariano Garcia-Arranz
Funding Agency and Grant Number
Corresponding Author	Hector Guadalajara, MD, PhD, General Surgery Unit, Hospital General de Villalba, Avda. Reyes Católicos, 2, 28040 Madrid, Spain. hector.guadalajara@fjd.es
Key Words	Fistula-in-ano; Crohn’s disease; Cell therapy; Adipose derived stem cells; Compassionate-use
Core Tip	Our group has been working with adipose stem cells (ASC) for several years now, performing various clinical trials. Patients with very complex fistulae, multiple previous surgeries and treatment failure are generally not able to enter these studies despite they would benefit the most, even as their “last chance” of cure. We present the results of a “Compassionate Use” Program, which enabled the application of stem cell therapy to these patients, under strict regulations. Ten patients were treated, and after one year of follow-up, we concluded that ASC are effective and safe, and 60% of the patients achieved complete healing.
Publish Date	2015-03-19 16:57
Citation	Garcia-Olmo D, Guadalajara H, Rubio-Perez I, Herreros MD, de-la-Quintana P, Garcia-Arranz M. Recurrent anal fistulae: Limited surgery supported by stem cells. World J Gastroenterol 2015; 21(11): 3330-3336
URL	http://www.wjgnet.com/1007-9327/full/v21/i11/3330.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i11.3330

Full Article (PDF)	WJG-21-3330.pdf
Full Article (Word)	WJG-21-3330.doc
Manuscript File	14413-Review.docx
Answering Reviewers	14413-Answering reviewers.pdf
Biostatistics Review Certificate	14413-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	14413-Conflict-of-interest statement.pdf
Copyright License Agreement	14413-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	14413-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	14413-Language certificate.pdf
Peer-review Report	14413-Peer-review(s).pdf
Scientific Misconduct Check	14413-CrossCheck.jpg
Scientific Editor Work List	14413-Scientific editor work list.pdf