Publication Name	World Journal of Gastroenterology
Manuscript ID	1445
Country	Taiwan

Received	2012-12-11 23:42
Peer-Review Started	2012-12-12 14:38
To Make the First Decision	2012-12-27 12:28
Return for Revision	2012-12-28 08:37
Revised	2013-01-14 20:02
Second Decision	2013-02-28 18:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-03-01 06:24
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-02 10:21
Publish the Manuscript Online	2013-05-14 16:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Autobiography
Article Title	Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats
Manuscript Source	Invited Manuscript
All Author List	Yu-Feng Tian, Chih-Tsueng He, Yu-Ting Chen and Po-Shiuan Hsieh
Funding Agency and Grant Number	Funding Agency Grant Number National Science Council of the ROC NSC98-2320-B-016-011 MY3 National Science Council of the ROC CMNDMC 100-05 National Science Council of the ROC TSGH-C100-011-015-S03
Corresponding Author	Po-Shiuan Hsieh, MD, PhD, Department of Physiology and Biophysics, National Defense Medical Center, 161, Section 6 Min-Chuan East Road, Taipei 114, Taiwan. pshsieh@hotmail.com
Key Words	Lipoic acid; Oxidative stress; Steatohepatitis; Portal endotoxemia; Insulin secretion; Fructose
Core Tip	α-lipoic acid (LA), a potent antioxidant and also an inducer of endogenous antioxidants has been reported to protect the liver and pancreas from injury. Our observations suggest that LA could significantly suppress inflammatory change of steatosis induced by low-dose intraportal lipopolysaccharide infusion and associated deterioration of insulin secretion in this metabolic syndrome rodent model. In addition, our data suggest that hepatic toll-like receptor 4 signaling might not only play a significant role in chronic fructosefeeding-induced hepatic steatosis but also in its subacute inflammatory change induced by mild portal endotoxemia and associated extrahepatic disorders.
Publish Date	2013-05-14 16:05
Citation	Tian YF, He CT, Chen YT, Hsieh PS. Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats. World J Gastroenterol 2013; 19(18): 2761-2771
URL	http://www.wjgnet.com/1007-9327/full/v19/i18/2761.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i18.2761

Full Article (PDF)	WJG-19-2761.pdf
Manuscript File	1445-Review.docx
Answering Reviewers	1445-Answering reviewers.doc
Copyright License Agreement	1445-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1445-Language certificate.pdf
Peer-review Report	1445-Peer review(s).docx
Scientific Editor Work List	1445-Scientific editor work list.doc