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Publication Name World Journal of Diabetes
Manuscript ID 14686
Country/Territory Türkiye
Received
2014-10-20 08:49
Peer-Review Started
2014-10-21 08:13
To Make the First Decision
2015-01-20 13:31
Return for Revision
2015-01-30 17:15
Revised
2015-02-23 23:08
Second Decision
2015-03-16 17:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-04-02 15:52
Articles in Press
2015-04-02 15:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-22 18:51
Publish the Manuscript Online
2015-07-10 18:24
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Review
Article Title Fetal programming of polycystic ovary syndrome
Manuscript Source Unsolicited Manuscript
All Author List Esra Bahar Gur, Muammer Karadeniz and Guluzar Arzu Turan
Funding Agency and Grant Number
Corresponding Author Muammer Karadeniz, MD, Department of Endocrinology, Faculty of Medicine, Sifa University, Sanayi St. No. 7, Bornova 35100, Turkey. muammermd@hotmail.com
Key Words Polycystic ovary syndrome; Androgens; Fetal programming; Intrauterine growth retardation; Genetic
Core Tip Polycystic ovary syndrome (PCOS) is a highly complex and heterogeneous disorder that is significantly influenced by genetic and environmental factors. There is some evidence that the development of PCOS may begin during the intrauterine period. Fetuses exposed to intrauterine nutritional restriction often have lowered insulin secretion and, as a compensatory mechanism, insulin resistance, which is known as the “thrifty” pheno-type. Additionally, an impaired intrauterine nutritional environment can affect the methylation of some specific genes, which can trigger PCOS. The other hypothesis postulates that fetal exposure to excess androgen can induce changes in differentiating tissues, causing the PCOS phenotype and related disorders to develop in adult life.
Publish Date 2015-07-10 18:24
Citation Gur EB, Karadeniz M, Turan GA. Fetal programming of polycystic ovary syndrome. World J Diabetes 2015; 6(7): 936-942
URL http://www.wjgnet.com/1948-9358/full/v6/i7/936.htm
DOI http://dx.doi.org/10.4239/wjd.v6.i7.936
Full Article (PDF) WJD-6-936.pdf
Full Article (Word) WJD-6-936.doc
Manuscript File 14686-Review.docx
Answering Reviewers 14686-Answering reviewers.pdf
Audio Core Tip 14686-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 14686-Conflict-of-interest statement.pdf
Copyright License Agreement 14686-Copyright assignment.pdf
Peer-review Report 14686-Peer-review(s).pdf
Scientific Misconduct Check 14686-Scientific misconduct check.pdf
Scientific Editor Work List 14686-Scientific editor work list.pdf