Publication Name	World Journal of Diabetes
Manuscript ID	14686
Country	Türkiye

Received	2014-10-20 08:49
Peer-Review Started	2014-10-21 08:13
To Make the First Decision	2015-01-20 13:31
Return for Revision	2015-01-30 17:15
Revised	2015-02-23 23:08
Second Decision	2015-03-16 17:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-04-02 15:52
Articles in Press	2015-04-02 15:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-22 18:51
Publish the Manuscript Online	2015-07-10 18:24

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Fetal programming of polycystic ovary syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Esra Bahar Gur, Muammer Karadeniz and Guluzar Arzu Turan
Funding Agency and Grant Number
Corresponding Author	Muammer Karadeniz, MD, Department of Endocrinology, Faculty of Medicine, Sifa University, Sanayi St. No. 7, Bornova 35100, Turkey. muammermd@hotmail.com
Key Words	Polycystic ovary syndrome; Androgens; Fetal programming; Intrauterine growth retardation; Genetic
Core Tip	Polycystic ovary syndrome (PCOS) is a highly complex and heterogeneous disorder that is significantly influenced by genetic and environmental factors. There is some evidence that the development of PCOS may begin during the intrauterine period. Fetuses exposed to intrauterine nutritional restriction often have lowered insulin secretion and, as a compensatory mechanism, insulin resistance, which is known as the “thrifty” pheno-type. Additionally, an impaired intrauterine nutritional environment can affect the methylation of some specific genes, which can trigger PCOS. The other hypothesis postulates that fetal exposure to excess androgen can induce changes in differentiating tissues, causing the PCOS phenotype and related disorders to develop in adult life.
Publish Date	2015-07-10 18:24
Citation	Gur EB, Karadeniz M, Turan GA. Fetal programming of polycystic ovary syndrome. World J Diabetes 2015; 6(7): 936-942
URL	http://www.wjgnet.com/1948-9358/full/v6/i7/936.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i7.936

Full Article (PDF)	WJD-6-936.pdf
Full Article (Word)	WJD-6-936.doc
Manuscript File	14686-Review.docx
Answering Reviewers	14686-Answering reviewers.pdf
Audio Core Tip	14686-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	14686-Conflict-of-interest statement.pdf
Copyright License Agreement	14686-Copyright assignment.pdf
Peer-review Report	14686-Peer-review(s).pdf
Scientific Misconduct Check	14686-Scientific misconduct check.pdf
Scientific Editor Work List	14686-Scientific editor work list.pdf