Publication Name	World Journal of Virology
Manuscript ID	14847
Country	Brazil

Received	2014-10-28 08:37
Peer-Review Started	2014-10-28 10:11
First Decision by Editorial Office Director
Return for Revision	2014-12-03 12:22
Revised	2015-01-15 20:10
Publication Fee Transferred
Second Decision by Editor	2015-02-27 09:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-03-09 17:21
Articles in Press	2015-03-09 17:21
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-17 17:25
Publish the Manuscript Online	2015-04-30 17:58

ISSN	2220-3249 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Infectious Diseases
Manuscript Type	Review
Article Title	Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs
Manuscript Source	Invited Manuscript
All Author List	Joel da Cunha, Luciana Morganti Ferreira Maselli, Ana Carolina Bassi Stern, Celso Spada and Sérgio Paulo Bydlowski
Funding Agency and Grant Number
Corresponding Author	Sérgio Paulo Bydlowski, MD, PhD, Associate Professor of Hematology, Director, Laboratory of Genetics and Molecular Hematology (LIM-31), University of São Paulo Medical School (FMUSP), Av. Dr. Enéas de Carvalho Aguiar, 155, 1 andar, Sala 43, São Paulo SP 05403-000, Brazil. spbydlow@usp.br
Key Words	Human immunodeficiency virus-1 infection; Highly active antiretroviral therapy; Protease inhibitors; Dyslipidemia; Atherosclerosis; Lipodystrophy; Statins; Fibrates; Diet; Lifestyle
Core Tip	Antiretroviral therapy inhibits human im?munodeficiency virus (HIV)-1 replication, reduces mortality and increases survival. On the other hand, HIV-1 infection and antiretroviral therapy affect lipid metabolism. In fact, lipodystrophy is a well-documented side effect of highly active antiretroviral therapy (HAART). Switching to a less metabolically active drug improve HAART-associated dyslipidemia. Other therapies may include statins, fibrates, inhibitors cholesterol absorption, fish oils, niacin. Moreover, changes in diet and lifestyle are needed to revert the dyslipidemia.
Publish Date	2015-04-30 17:58
Citation	da Cunha J, Maselli LMF, Stern ACB, Spada C, Bydlowski SP. Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs. World J Virol 2015; 4(2): 56-77
URL	http://www.wjgnet.com/2220-3249/full/v4/i2/56.htm
DOI	http://dx.doi.org/10.5501/wjv.v4.i2.56

Full Article (PDF)	WJV-4-56.pdf
Full Article (Word)	WJV-4-56.doc
Manuscript File	14847-Review.docx
Answering Reviewers	14847-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14847-Conflict-of-interest statement.pdf
Copyright License Agreement	14847-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	14847-Language certificate.pdf
Peer-review Report	14847-Peer-review(s) .pdf
Scientific Misconduct Check	14847-Scientific misconduct check.pdf
Scientific Editor Work List	14847-Scientific editor work list.pdf