Publication Name	World Journal of Gastroenterology
Manuscript ID	15090
Country	China

Received	2014-11-08 12:14
Peer-Review Started	2014-11-08 21:35
To Make the First Decision	2014-12-11 20:23
Return for Revision	2014-12-16 08:57
Revised	2014-12-22 21:22
Second Decision	2014-12-26 13:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-01-08 17:27
Articles in Press	2015-01-08 17:35
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-01-28 02:07
Typeset the Manuscript	2015-05-18 17:27
Publish the Manuscript Online	2015-06-11 10:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation
Manuscript Source	Unsolicited Manuscript
All Author List	Xu-Feng Lu, Yong-Jie Zhou, Lei Zhang, Hong-Jie Ji, Li Li, Yu-Jun Shi and Hong Bu
Funding Agency and Grant Number	Funding Agency Grant Number National Key Clinical Project National Sciences Technology Major Project of China 2012ZX10002-017
Corresponding Author	Yu-Jun Shi, MD, PhD, Laboratory of Pathology, West China Hospital, Sichuan University, 37 Wainan Guoxuexiang, Chengdu 610041, Sichuan Province, China. shiyujun@scu.edu.cn
Key Words	Dicer1; microRNAs; Liver inflammation; Liver fibrosis; Hepatocellular carcinoma
Core Tip	MicroRNAs (miRNAs) play a critical role in the regulation of multiple biological genes in the liver. The liver-specific loss of Dicer1, an endoribonuclease essential for precursor miRNAs maturation, results in liver injury and spontaneous development of hepatocellular carcinoma (HCC); however, the gradual histological changes involved in these processes have not been completely characterized. In contrast to previous reports, we found that Dicer1 inactivation causes typical chronic liver injury characterized by profound hepatocyte apoptosis, continuous liver necrosis, active compensatory proliferation, noticeable triad inflammation, progressive liver fibrosis, significant progenitor activation, and spontaneous hepatocarcinogenesis. Our work provides new insights into the role of miRNA in liver injury and HCC development. These results may also aid in the development of a miRNA therapeutic strategy for the prevention and treatment of HCC.
Publish Date	2015-06-11 10:11
Citation	Lu XF, Zhou YJ, Zhang L, Ji HJ, Li L, Shi YJ, Bu H. Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation. World J Gastroenterol 2015; 21(21): 6591-6603
URL	http://www.wjgnet.com/1007-9327/full/v21/i21/6591.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i21.6591

Full Article (PDF)	WJG-21-6591.pdf
Full Article (Word)	WJG-21-6591.doc
Manuscript File	15090-Review.docx
Answering Reviewers	15090-Answering reviewers.pdf
Biostatistics Review Certificate	15090-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	15090-Conflict-of-interest statement.pdf
Copyright License Agreement	15090-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	15090-Institutional Animal Care and Use Committee (IACUC) statement.pdf
Institutional Review Board Approval Form or Document	15090-Institutional Review Board (IRB) statement approval.pdf
Non-Native Speakers of English Editing Certificate	15090-Language CertifIcate.pdf
Peer-review Report	15090-Peer review(s).pdf
Scientific Misconduct Check	15090-CorssCheck.jpg
Scientific Editor Work List	15090-Scientific editor work list.pdf