Publication Name	World Journal of Gastroenterology
Manuscript ID	15109
Country	Italy

Received	2014-11-08 21:30
Peer-Review Started	2014-11-08 21:55
To Make the First Decision	2014-11-26 18:22
Return for Revision	2014-11-28 14:11
Revised	2014-12-17 06:04
Second Decision	2015-01-19 16:43
Accepted by Journal Editor-in-Chief	2015-01-21 19:40
Accepted by Company Editor-in-Chief	2015-01-30 15:30
Articles in Press	2015-01-30 18:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-07 19:06
Publish the Manuscript Online	2015-02-28 17:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Use of non-selective beta blockers in cirrhosis: The evidence we need before closing (or not) the window
Manuscript Source	Invited Manuscript
All Author List	Vincenzo La Mura, Giulia Tosetti, Massimo Primignani and Francesco Salerno
Funding Agency and Grant Number
Corresponding Author	Vincenzo La Mura, MD, PhD, U.O. Medicina Interna, IRCCS-San Donato, Dipartimento di Scienze Biomediche per la Salute, Università degli studi di Milano, Via Morandi 30, San Donato Milanese, 20097 Milan, Italy. vin.lamura@gmail.com
Key Words	Bleeding prophylaxis; End stage liver disease; Non-selective beta blockers; Portal hypertension; Cirrhosis
Core Tip	Non selective beta blockers (NSBBs) treatment in cirrhotic patients is an undisputed strategy for bleeding prophylaxis. Nevertheless recent studies question the efficacy and safety of NSBBs in patient with advanced cirrhosis, particularly in case of re?fractory ascites and spontaneous bacterial peritonitis. These results suggest that NSBBs have beneficial effects on cirrhosis only in a determinate phase of the liver disease: “window hypothesis”. In our opinion, the evidence produced up to now is by far conclusive to contraindicate NSBBs in patients with advanced cirrhosis.
Publish Date	2015-02-28 17:07
Citation	La Mura V, Tosetti G, Primignani M, Salerno F. Use of non-selective beta blockers in cirrhosis: The evidence we need before closing (or not) the window. World J Gastroenterol 2015; 21(8): 2265-2268
URL	http://www.wjgnet.com/1007-9327/full/v21/i8/2265.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i8.2265

Full Article (PDF)	WJG-21-2265.pdf
Full Article (Word)	WJG-21-2265.doc
Manuscript File	15109-Review.docx
Answering Reviewers	15109-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15109-Conflict-of-interest statement.pdf
Copyright License Agreement	15109-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	15109-Language certificate.pdf
Peer-review Report	15109-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15109-Journal Editor-in-Chief's Review Report.pdf
Scientific Misconduct Check	15109-CorssCheck.jpg
Scientific Editor Work List	15109-Scientific editor work list.pdf