Publication Name	World Journal of Gastroenterology
Manuscript ID	15230
Country	Japan

Received	2014-11-17 09:43
Peer-Review Started	2014-11-17 19:13
To Make the First Decision	2014-12-26 13:27
Return for Revision	2014-12-29 11:09
Revised	2015-03-01 23:05
Second Decision	2015-03-11 15:30
Accepted by Journal Editor-in-Chief	2015-03-12 09:51
Accepted by Executive Editor-in-Chief	2015-03-19 17:25
Articles in Press	2015-03-19 17:47
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-05-06 04:51
Typeset the Manuscript	2015-06-16 09:51
Publish the Manuscript Online	2015-07-14 12:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Anti-inflammatory effect of recombinant thrombomodulin for fulminant hepatic failure
Manuscript Source	Unsolicited Manuscript
All Author List	Kazutaka Kurokohchi, Osamu Imataki and Fumiyoshi Kubo
Funding Agency and Grant Number
Corresponding Author	Dr. Osamu Imataki, Division of Hematology and Stem Cell Transplantation, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. oima@med.kagawa-u.ac.jp
Key Words	Fulminant hepatic failure; Disseminated intravascular coagulation; Thrombomodulin; Hepatocyte growth factor; Systemic inflammatory response syndrome
Core Tip	Fulminant hepatic failure (FHF) is a critical illness that can be comorbid to primary liver damage. However, no standard therapy for the treatment of FHF has been established. We experienced a fatal FHF case with systemic inflammatory response syndrome followed by disseminated intravascular coagulopathy (DIC). We administered recombinant thrombomodulin (rTM) for the treatment of DIC, which ameliorated all lethal conditions (coagulopathy and inflammation). Monitoring of proinflammatory cytokines, hepatocyte growth factor, and prothrombin time revealed the response of FHF to rTM. We hypothesized an anti-inflammatory effect of rTM-enhanced hepatocyte regeneration through inactivation of high-mobility group box 1.
Publish Date	2015-07-14 12:17
Citation	Kurokohchi K, Imataki O, Kubo F. Anti-inflammatory effect of recombinant thrombomodulin for fulminant hepatic failure. World J Gastroenterol 2015; 21(26): 8203-8207
URL	http://www.wjgnet.com/1007-9327/full/v21/i26/8203.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i26.8203

Full Article (PDF)	WJG-21-8203.pdf
Full Article (Word)	WJG-21-8203.doc
Manuscript File	15230-Review.docx
Answering Reviewers	15230-Answering reviewers.pdf
Copyright License Agreement	15230-Copyright assignment.pdf
Peer-review Report	15230-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15230-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15230-Scientific misconduct check.pdf
Scientific Editor Work List	15230-Scientific editor work list.pdf