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Articles Published Processes
11/23/2015 11:10:00 AM | Browse: 1070 | Download: 1727
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Received |
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2014-11-28 10:03 |
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Peer-Review Started |
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2014-11-29 13:20 |
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To Make the First Decision |
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2014-12-26 13:17 |
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Return for Revision |
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2015-01-01 14:23 |
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Revised |
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2015-01-20 08:34 |
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Second Decision |
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2015-08-20 16:14 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-08-31 15:25 |
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Articles in Press |
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2015-08-31 15:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-11-04 09:45 |
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Publish the Manuscript Online |
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2015-11-23 10:19 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
DNA microarray unravels rapid changes in transcriptome of MK-801 treated rat brain
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yuka Kobayashi, Sofya P Kulikova, Junko Shibato, Randeep Rakwal, Hiroyuki Satoh, Didier Pinault and Yoshinori Masuo |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Randeep Rakwal, Professor, Faculty of Health and Sport Sciences and Tsukuba International Academy for Sport Studies, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8574, Japan. plantproteomics@gmail.com |
| Key Words |
Dizocilpine; Dye-swap; Gene expression; Microarray; MK801; N-Methyl-D-aspartate receptors |
| Core Tip |
N-Methyl-D-aspartate receptors (NMDAr) are involved in multiple physiological functions and neuropsychiatric disorders. Dizocilpine (commonly referred to as MK-801) is a well-known non-competitive NMDAr antagonist with psychotomimetic properties. A combination of electro?physiological and molecular analyses reveals not only the synchrony of baseline oscillations by MK-801, but also more importantly new insight into differential gene expressions in the cerebral cortex, midbrain, hippocampus, ventral striatum, amygdala, and hypothalamus regions after acute low-dose (0.08 mg/kg) MK-801 treatment; only the ventral striatum showed increased gene expression at a high dose (0.16 mg/kg) of MK-801. We believe that our present study will contribute in the understanding of the pathogenic mechanisms of neuropsychiatric disorders. |
| Publish Date |
2015-11-23 10:19 |
| Citation |
Kobayashi Y, Kulikova SP, Shibato J, Rakwal R, Satoh H, Pinault D, Masuo Y. DNA microarray unravels rapid changes in transcriptome of MK-801 treated rat brain. World J Biol Chem 2015; 6(4): 389-408 |
| URL |
http://www.wjgnet.com/1949-8454/full/v6/i4/389.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v6.i4.389 |
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