Publication Name	World Journal of Biological Chemistry
Manuscript ID	15450
Country	Japan

Received	2014-11-28 10:03
Peer-Review Started	2014-11-29 13:20
First Decision by Editorial Office Director
Return for Revision	2015-01-01 14:23
Revised	2015-01-20 08:34
Publication Fee Transferred
Second Decision by Editor	2015-08-20 16:14
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-08-31 15:25
Articles in Press	2015-08-31 15:25
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-04 09:45
Publish the Manuscript Online	2015-11-23 10:19

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Neurosciences
Manuscript Type	Basic Study
Article Title	DNA microarray unravels rapid changes in transcriptome of MK-801 treated rat brain
Manuscript Source	Invited Manuscript
All Author List	Yuka Kobayashi, Sofya P Kulikova, Junko Shibato, Randeep Rakwal, Hiroyuki Satoh, Didier Pinault and Yoshinori Masuo
Funding Agency and Grant Number
Corresponding Author	Dr. Randeep Rakwal, Professor, Faculty of Health and Sport Sciences and Tsukuba International Academy for Sport Studies, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8574, Japan. plantproteomics@gmail.com
Key Words	Dizocilpine; Dye-swap; Gene expression; Microarray; MK801; N-Methyl-D-aspartate receptors
Core Tip	N-Methyl-D-aspartate receptors (NMDAr) are involved in multiple physiological functions and neuropsychiatric disorders. Dizocilpine (commonly referred to as MK-801) is a well-known non-competitive NMDAr antagonist with psychotomimetic properties. A combination of electro?physiological and molecular analyses reveals not only the synchrony of baseline oscillations by MK-801, but also more importantly new insight into differential gene expressions in the cerebral cortex, midbrain, hippocampus, ventral striatum, amygdala, and hypothalamus regions after acute low-dose (0.08 mg/kg) MK-801 treatment; only the ventral striatum showed increased gene expression at a high dose (0.16 mg/kg) of MK-801. We believe that our present study will contribute in the understanding of the pathogenic mechanisms of neuropsychiatric disorders.
Publish Date	2015-11-23 10:19
Citation	Kobayashi Y, Kulikova SP, Shibato J, Rakwal R, Satoh H, Pinault D, Masuo Y. DNA microarray unravels rapid changes in transcriptome of MK-801 treated rat brain. World J Biol Chem 2015; 6(4): 389-408
URL	http://www.wjgnet.com/1949-8454/full/v6/i4/389.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i4.389

Full Article (PDF)	WJBC-6-389.pdf
Full Article (Word)	WJBC-6-389.doc