Publication Name	World Journal of Transplantation
Manuscript ID	15491
Country	Italy

Received	2014-11-27 19:45
Peer-Review Started	2014-11-28 15:49
To Make the First Decision	2014-12-26 13:17
Return for Revision	2015-01-01 16:57
Revised	2015-01-12 00:39
Second Decision	2015-04-15 17:58
Accepted by Journal Editor-in-Chief	2015-04-16 18:00
Accepted by Executive Editor-in-Chief	2015-04-29 15:35
Articles in Press	2015-04-29 15:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-11 15:09
Publish the Manuscript Online	2015-06-19 15:49

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Transplantation
Manuscript Type	Review
Article Title	Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment
Manuscript Source	Invited Manuscript
All Author List	Maurizio Salvadori, Giuseppina Rosso and Elisabetta Bertoni
Funding Agency and Grant Number
Corresponding Author	Maurizio Salvadori, MD, Department of Renal Transplantation, Careggi University Hospital, viale Pieraccini 18, 50139 Florence, Italy. maurizio.salvadori1@gmail.com
Key Words	Ischemia-reperfusion; Delayed graft fun­ction; Inflammatory response; Acute kidney injury; Innate and adaptive immune response; Anti-inflam­matory strategies
Core Tip	In kidney transplantation the ischemia reper-fusion injury is a severe unavoidable consequence that may impact the graft outcome. The underlying mecha-nisms are not completely understood and new findings are continuously being discovered. These involve the biological cellular mechanisms and the gene related response to injury as ischemia and reperfusion. Therapeutically, is extremely important to control this severe complication. Several drugs and strategies are now available and a number of international trials are ongoing. In addition future therapies are now in the pipeline and will be described in this manuscript.
Publish Date	2015-06-19 15:49
Citation	Salvadori M, Rosso G, Bertoni E. Update on ischemia-reper­fusion injury in kidney transplantation: Pathogenesis and treatment. World J Transplant 2015; 5(2): 52-67
URL	http://www.wjgnet.com/2220-3230/full/v5/i2/52.htm
DOI	http://dx.doi.org/10.5500/wjt.v5.i2.52

Full Article (PDF)	WJT-5-52.pdf
Full Article (Word)	WJT-5-52.doc
Manuscript File	15491-Review.docx
Answering Reviewers	15491-Answering reviewers.pdf
Audio Core Tip	15491-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	15491-Conflict-of-interest statement.pdf
Copyright License Agreement	15491-Copyright assignment.pdf
Peer-review Report	15491-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	15491-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	15491-Scientific misconduct check.pdf
Scientific Editor Work List	15491-Scientific editor work list.pdf