Publication Name	World Journal of Nephrology
Manuscript ID	15495
Country	Germany

Received	2014-11-27 20:10
Peer-Review Started	2014-11-28 15:42
To Make the First Decision	2014-12-26 13:16
Return for Revision	2015-01-01 17:02
Revised	2015-01-12 21:59
Second Decision	2015-04-22 17:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-05-06 15:35
Articles in Press	2015-05-06 15:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-30 14:14
Publish the Manuscript Online	2015-07-06 18:45

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Critical Care Medicine
Manuscript Type	Review
Article Title	Pharmacokinetic and pharmacodynamic considerations of antimicrobial drug therapy in cancer patients with kidney dysfunction
Manuscript Source	Invited Manuscript
All Author List	Frieder Keller, Bernd Schröppel and Ulla Ludwig
Funding Agency and Grant Number
Corresponding Author	Frieder Keller, MD, Section of Nephrology, Department of Internal Medicine 1, Center for Internal Medicine, University Hospital, Albert-Einstein-Allee 23, D-89070 Ulm, Germany. frieder.keller@uni-ulm.de
Key Words	Anti-infective drugs; Cancer; Kidney function; Pharmacodynamics; Pharmacokinetics; Dose adjustmen; NEPharm
Core Tip	Cancer patients are at an increased risk for both infection and kidney dysfunction. Infections need immediate treatment; during the further course, kidney function must be taken into account. Almost any drug can be adjusted to any kidney function in every patient. Observation of the pharmacokinetic principles allows avoiding adverse events. Observation of the pharmacodynamic principles is needed to obtain anti-infective success. The target concentration for anti-infective drugs with a concentration-dependent effect is the high peak level. The target concentration for anti-infective drugs with a time-dependent effect is the high trough level. When in doubt, the peak should be the target.
Publish Date	2015-07-06 18:45
Citation	Keller F, Schröppel B, Ludwig U. Pharmacokinetic and pharmacodynamic considerations of antimicrobial drug therapy in cancer patients with kidney dysfunction. World J Nephrol 2015; 4(3): 330-344
URL	http://www.wjgnet.com/2220-6124/full/v4/i3/330.htm
DOI	http://dx.doi.org/10.5527/wjn.v4.i3.330

Full Article (PDF)	WJN-4-330.pdf
Full Article (Word)	WJN-4-330.doc
Manuscript File	15495-Review.docx
Answering Reviewers	15495-Answering reviewers.pdf
Audio Core Tip	15495-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	15495-Conflict-of-interest statement.pdf
Copyright License Agreement	15495-Copyright assignment.pdf
Peer-review Report	15495-Peer-review(s).pdf
Scientific Misconduct Check	15495-Scientific misconduct check.pdf
Scientific Editor Work List	15495-Scientific editor work list.pdf