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6/29/2015 4:40:00 PM | Browse: 661 | Download: 847
Publication Name World Journal of Gastroenterology
Manuscript ID 15500
Country of Manuscript Source Spain
Received
2014-11-28 09:38
Peer-Review Started
2014-11-28 10:55
To Make the First Decision
2014-12-26 13:22
Return for Revision
2014-12-31 09:14
Revised
Second Decision
2015-02-11 22:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-02-13 10:33
Articles in Press
2015-02-13 11:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-05-23 05:25
Typeset the Manuscript
2015-06-12 11:59
Publish the Manuscript Online
2015-06-29 16:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Observational Study
Article Title Liver fat deposition and mitochondrial dysfunction in morbid obesity: An approach combining metabolomics with liver imaging and histology
Manuscript Source Unsolicited Manuscript
All Author List Nahum Calvo, Raúl Beltrán-Debón, Esther Rodríguez-Gallego, Anna Hernández-Aguilera, Maria Guirro, Roger Mariné-Casadó, Lidón Millá, Josep M Alegret, Fàtima Sabench, Daniel del Castillo, María Vinaixa, Miguel Àngel Rodríguez, Xavier Correig, Roberto García-Álvarez, Javier A Menendez, Jordi Camps and Jorge Joven
Funding Agency and Grant Number
Funding Agency Grant Number
Universitat Rovira I Virgili and the Hospital de Sant Joan de Reus
Carlos III Health Institute, Madrid, Spain PI08/1381
European Fund for Regional Development PI11/00130
Corresponding author Jorge Joven, MD, PhD, Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Campus of International Excellence Southern Catalonia, c/ Sant Llorenç 21, 43201 Reus, Spain. jorge.joven@urv.cat
Keywords Fatty liver disease; Magnetic resonance imaging; Lipids; Magnetic resonance spectroscopy; Metabolomics; Mitochondrial function; Morbid obesity; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis
Core Tip Despite remaining obese, non-alcoholic fatty liver disease (NAFLD) regressed in patients undergoing bariatric surgery. Magnetic resonance imaging was sufficient to assess these findings and spectroscopy and measurement of liver fat content were superfluous for this purpose. Patients were free of hepatocyte ballooning or fibrosis and results may limit further the indication for liver biopsy to patients with known factors affecting the progression of liver disease. Additional information on the dissociation between lipid storage in adipose tissue and NAFLD suggests the presence of mitochondrial and inflammatory disease and may focus on the unmet need for plasma biomarkers of circulating metabolites produced during altered cellular fatty oxidation and glycolysis.
Publish Date 2015-06-29 16:33
Citation Calvo N, Beltrán-Debón R, Rodríguez-Gallego E, Hernández-Aguilera A, Guirro M, Mariné-Casadó R, Millá L, Alegret JM, Sabench F, del Castillo D, Vinaixa M, Rodríguez MA, Correig X, García-Álvarez R, Menendez JA, Camps J, Joven J. Liver fat deposition and mitochondrial dysfunction in morbid obesity: An approach combining metabolomics with liver imaging and histology. World J Gastroenterol 2015; 21(24): 7529-7544
Url http://www.wjgnet.com/1007-9327/full/v21/i24/7529.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i24.7529
Full Article (PDF) WJG-21-7529.pdf
Full Article (Word) WJG-21-7529.doc
Manuscript File 15500-Review.docx
Answering Reviewers 15500-Answering reviewers.pdf
Biostatistics Review Certificate 15500-Biostatistics statement.pdf
Clinical Trial Registration Statement DeclarationOf_HelsinkiConformation_Statement_20141127223111.pdf
Conflict-of-Interest Disclosure Form 15500-Conflict-of-interest statement.pdf
Copyright License Agreement 15500-Copyright assignment.pdf
Data Sharing Statement 15500-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20141127222933.pdf
Institutional Animal Care and Use Committee Approval Form or Document Institutional_Animal_Care_and_Use_Committee_Statement_20141127223134.pdf
Institutional Review Board Approval Form or Document 15500-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate Editing_Certificate_20141127222722.pdf
Peer-review Report 15500-Peer-review(s).pdf
Scientific Misconduct Check 15500-Scientific misconduct check.pdf
Scientific Editor Work List 15500-Scientific editor work list.pdf