ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Medicine, Research & Experimental |
Manuscript Type |
Observational Study |
Article Title |
Liver fat deposition and mitochondrial dysfunction in morbid obesity: An approach combining metabolomics with liver imaging and histology
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Nahum Calvo, Raúl Beltrán-Debón, Esther Rodríguez-Gallego, Anna Hernández-Aguilera, Maria Guirro, Roger Mariné-Casadó, Lidón Millá, Josep M Alegret, Fàtima Sabench, Daniel del Castillo, María Vinaixa, Miguel Àngel Rodríguez, Xavier Correig, Roberto García-Álvarez, Javier A Menendez, Jordi Camps and Jorge Joven |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Universitat Rovira I Virgili and the Hospital de Sant Joan de Reus |
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Carlos III Health Institute, Madrid, Spain |
PI08/1381 |
European Fund for Regional Development |
PI11/00130 |
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Corresponding Author |
Jorge Joven, MD, PhD, Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Campus of International Excellence Southern Catalonia, c/ Sant Llorenç 21, 43201 Reus, Spain. jorge.joven@urv.cat |
Key Words |
Fatty liver disease; Magnetic resonance imaging; Lipids; Magnetic resonance spectroscopy; Metabolomics; Mitochondrial function; Morbid obesity; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis |
Core Tip |
Despite remaining obese, non-alcoholic fatty liver disease (NAFLD) regressed in patients undergoing bariatric surgery. Magnetic resonance imaging was sufficient to assess these findings and spectroscopy and measurement of liver fat content were superfluous for this purpose. Patients were free of hepatocyte ballooning or fibrosis and results may limit further the indication for liver biopsy to patients with known factors affecting the progression of liver disease. Additional information on the dissociation between lipid storage in adipose tissue and NAFLD suggests the presence of mitochondrial and inflammatory disease and may focus on the unmet need for plasma biomarkers of circulating metabolites produced during altered cellular fatty oxidation and glycolysis. |
Publish Date |
2015-06-29 16:33 |
Citation |
Calvo N, Beltrán-Debón R, Rodríguez-Gallego E, Hernández-Aguilera A, Guirro M, Mariné-Casadó R, Millá L, Alegret JM, Sabench F, del Castillo D, Vinaixa M, Rodríguez MA, Correig X, García-Álvarez R, Menendez JA, Camps J, Joven J. Liver fat deposition and mitochondrial dysfunction in morbid obesity: An approach combining metabolomics with liver imaging and histology. World J Gastroenterol 2015; 21(24): 7529-7544 |
URL |
http://www.wjgnet.com/1007-9327/full/v21/i24/7529.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v21.i24.7529 |