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4/7/2015 6:08:00 PM | Browse: 1343 | Download: 1354
Publication Name World Journal of Gastroenterology
Manuscript ID 15525
Country/Territory United Kingdom
Received
2014-11-28 08:23
Peer-Review Started
2014-11-28 09:19
To Make the First Decision
2014-12-26 13:22
Return for Revision
2014-12-31 09:15
Revised
2015-01-09 00:10
Second Decision
2015-02-11 22:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-02-13 10:36
Articles in Press
2015-02-13 11:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-03-23 14:38
Publish the Manuscript Online
2015-04-07 17:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Editorial
Article Title Field cancerisation in colorectal cancer: A new frontier or pastures past?
Manuscript Source Invited Manuscript
All Author List Abhilasha Patel, Gyanendra Tripathi, Kishore Gopalakrishnan, Nigel Williams and Ramesh P Arasaradnam
Funding Agency and Grant Number
Funding Agency Grant Number
Bowel Disease Research Foundation, United Kingdom
Corresponding Author Abhilasha Patel, Research Registrar, Department of Colorectal Surgery, University Hospitals of Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry CV2 2DX, United Kingdom. abhilasha.patel@doctors.org.uk
Key Words Colorectal cancer; Carcinogenesis; Biomarkers; Epigenetics; Synchronous
Core Tip There is a great deal of interest in developing non- invasive tests that are able to detect colorectal cancer in the asymptomatic population. Most current research activity is focussed on investigating the biological changes found in tumour tissue itself. This review evaluates the biological alterations found in the normal mucosa around a neoplastic lesion and critically analyses the concept of field cancerisation. It highlights recent advances and identifies important molecular targets that could play a role in early colorectal carcinogenesis. In particular, the available evidence for field cancerisation is scrutinised and future avenues for further scientific enquiry are outlined.
Publish Date 2015-04-07 17:13
Citation Patel A, Tripathi G, Gopalakrishnan K, Williams N, Arasaradnam RP. Field cancerisation in colorectal cancer: A new frontier or pastures past? World J Gastroenterol 2015; 21(13): 3763-3772
URL http://www.wjgnet.com/1007-9327/full/v21/i13/3763.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i13.3763
Full Article (PDF) WJG-21-3763.pdf
Full Article (Word) WJG-21-3763.doc
Manuscript File 15525-Review.docx
Answering Reviewers 15525-Answering reviewers.PDF
Copyright License Agreement 15525-Copyright assignment.PDF
Peer-review Report 15525-Peer-review(s).pdf
Scientific Misconduct Check 15525-Scientific misconduct check.pdf
Scientific Editor Work List 15525-Scientific editor work list.pdf