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Articles Published Processes
5/19/2015 5:28:00 PM | Browse: 1326 | Download: 2201
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Received |
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2014-11-28 08:20 |
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Peer-Review Started |
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2014-12-02 16:35 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2015-01-14 12:16 |
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Revised |
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2015-01-28 07:39 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2015-02-10 16:17 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2015-02-12 14:28 |
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Articles in Press |
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2015-02-12 14:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-04-30 11:51 |
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Publish the Manuscript Online |
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2015-05-19 17:28 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Clinical relevance of hepatitis B virus variants
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shan Gao, Zhong-Ping Duan and Carla S Coffin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science and Technology Key Project of China on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment” |
2013-ZX10002002-006 (to Duan ZP) |
| Speaker, advisory board and/or consulting fees from Boehringer ingelheim, GlaxoSmithKline, Janssen Pharmaceuticals, Bristol Myers Squibb, Roche Pharmaceuticals and Gilead Sciences |
to Coffin CS |
| Canadian Institutes for Health Research |
to Coffin CS |
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| Corresponding Author |
Carla S Coffin, MD, MSc, FRCPC, Liver Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, 2500 University Drive Northwest, Calgary, Alberta T2N 4Z6,
Canada. cscoffin@ucalgary.ca
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| Key Words |
Molecular virology; Genetic heterogeneity; Quasispecies; Drug resistance; Immune escape; Viral lymphotropism; Hepatitis B virus |
| Core Tip |
The hepatitis B virus (HBV) has significant genomic diversity and some HBV variants are associated with antiviral therapy response, vaccine escape, diagnostic failure, liver fibrosis progression and hepato-cellular carcinoma development. Understanding HBV molecular epidemiology as well as the clinical and pathological relevence of HBV variants during different disease phases may enable more accurate risk-stratification of individual patients at risk for serious sequelae of chronic hepatitis B infection.
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| Publish Date |
2015-05-19 17:28 |
| Citation |
Gao S, Duan ZP, Coffin CS. Clinical relevance of hepatitis B virus variants. World J Hepatol 2015; 7(8): 1086-1096 |
| URL |
http://www.wjgnet.com/1948-5182/full/v7/i8/1086.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v7.i8.1086 |
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