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5/19/2015 5:28:00 PM | Browse: 1012 | Download: 1371
Publication Name World Journal of Hepatology
Manuscript ID 15526
Country/Territory Canada
Received
2014-11-28 08:20
Peer-Review Started
2014-12-02 16:35
To Make the First Decision
2015-01-08 14:01
Return for Revision
2015-01-14 12:16
Revised
2015-01-28 07:39
Second Decision
2015-02-10 16:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-02-12 14:28
Articles in Press
2015-02-12 14:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-04-30 11:51
Publish the Manuscript Online
2015-05-19 17:28
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Clinical relevance of hepatitis B virus variants
Manuscript Source Invited Manuscript
All Author List Shan Gao, Zhong-Ping Duan and Carla S Coffin
Funding Agency and Grant Number
Funding Agency Grant Number
National Science and Technology Key Project of China on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment” 2013-ZX10002002-006 (to Duan ZP)
Speaker, advisory board and/or consulting fees from Boehringer ingelheim, GlaxoSmithKline, Janssen Pharmaceuticals, Bristol Myers Squibb, Roche Pharmaceuticals and Gilead Sciences to Coffin CS
Canadian Institutes for Health Research to Coffin CS
Corresponding Author Carla S Coffin, MD, MSc, FRCPC, Liver Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, 2500 University Drive Northwest, Calgary, Alberta T2N 4Z6, Canada. cscoffin@ucalgary.ca
Key Words Molecular virology; Genetic heterogeneity; Quasispecies; Drug resistance; Immune escape; Viral lymphotropism; Hepatitis B virus
Core Tip The hepatitis B virus (HBV) has significant genomic diversity and some HBV variants are associated with antiviral therapy response, vaccine escape, diagnostic failure, liver fibrosis progression and hepato-cellular carcinoma development. Understanding HBV molecular epidemiology as well as the clinical and pathological relevence of HBV variants during different disease phases may enable more accurate risk-stratification of individual patients at risk for serious sequelae of chronic hepatitis B infection.
Publish Date 2015-05-19 17:28
Citation Gao S, Duan ZP, Coffin CS. Clinical relevance of hepatitis B virus variants. World J Hepatol 2015; 7(8): 1086-1096
URL http://www.wjgnet.com/1948-5182/full/v7/i8/1086.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i8.1086
Full Article (PDF) WJH-7-1086.pdf
Full Article (Word) WJH-7-1086.doc
Manuscript File 15526-Review.docx
Answering Reviewers 15526-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 15526-Conflict-of-interest statement.pdf
Copyright License Agreement 15526-Copyright assignment.pdf
Video 15226-Video core tip.mp4
Peer-review Report 15526-Peer-review(s).pdf
Scientific Misconduct Check 15526-Scientific misconduct check.pdf
Scientific Editor Work List 15526-Scientific editor work list.pdf