Publication Name	World Journal of Gastroenterology
Manuscript ID	1555
Country	France

Received	2012-12-19 17:13
Peer-Review Started	2012-12-20 15:21
To Make the First Decision	2013-01-24 18:46
Return for Revision	2013-01-29 11:03
Revised	2013-02-22 16:41
Second Decision	2013-03-22 12:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-03-23 09:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-25 11:12
Publish the Manuscript Online	2013-06-04 12:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: A feasibility study
Manuscript Source	Invited Manuscript
All Author List	Stephane Supiot, Wilfried Gouraud, Loïc Campion, Pascal Jezéquel, Bruno Buecher, Josiane Charrier, Marie-Francoise Heymann, Marc-Andre Mahé, Emmanuel Rio and Michel Chérel
Funding Agency and Grant Number	Funding Agency Grant Number Ligue Contre le Cancer, Programme Hospitalier de Recherche Clinique 20-R6
Corresponding Author	Michel Chérel, PhD, INSERM U892, Centre de Recherche en Cancérologie Nantes-Angers, University of Nantes, 8 quai Moncousu - BP 70721, 44000 Nantes, France. michel.cherel@univ-nantes.fr
Key Words	CCL28; CLIC5; PDCD4; RAB27A; TXNIP; Protein metabolism; Cell adhesion; Cell migration; SPON1; Carboxypeptidase E
Core Tip	To develop novel biomarkers of radiotherapy for rectal cancer, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy in a pilot study. Microarray analysis showed that preoperative radiotherapy significantly up-regulated 31 genes and down-regulated 6 genes, involved in protein metabolism, ion transport, transcription, signal transduction, cell adhesion, immune response and apoptosis. Micro-arrays could efficiently assess early transcriptomic changes during preoperative radiotherapy for rectal cancer. This may help better understand tumor radioresistance.
Publish Date	2013-06-04 12:34
Citation	Supiot S, Gouraud W, Campion L, Jezéquel P, Buecher B, Charrier J, Heymann MF, Mahé MA, Rio E, Chérel M. Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: A feasibility study. World J Gastroenterol 2013; 19(21): 3249-3254
URL	http://www.wjgnet.com/1007-9327/full/v19/i21/3249.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i21.3249

Full Article (PDF)	WJG-19-3249.pdf
Manuscript File	1555-Review.docx
Answering Reviewers	1555-Answering reviewers.docx
Copyright License Agreement	1555-Copyright assignment.pdf
Peer-review Report	1555-Peer reviewer(s).pdf
Scientific Editor Work List	1555-Scientific editor work list.doc