Publication Name	World Journal of Clinical Cases
Manuscript ID	15578
Country

Received	2014-11-29 13:14
Peer-Review Started	2014-11-29 15:20
To Make the First Decision	2015-02-07 14:48
Return for Revision	2015-02-11 19:16
Revised	2015-02-27 23:46
Second Decision	2015-05-08 17:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-05-18 17:17
Articles in Press	2015-05-18 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-09 17:15
Publish the Manuscript Online	2015-07-27 18:31

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Review
Article Title	From variome to phenome: Pathogenesis, diagnosis and management of ectopic mineralization disorders
Manuscript Source	Invited Manuscript
All Author List	Eva YG De Vilder and Olivier M Vanakker
Funding Agency and Grant Number
Corresponding Author	Vanakker M Olivier, MD, PhD, Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, East Flanders, Belgium. olivier.vanakker@ugent.be
Key Words	Ectopic mineralization; Pseudoxanthoma elasticum; Pseudoxanthoma elasticum-like syndrome; Generalized arterial calcification of infancy; Keutel syndrome; Idiopathic basal ganglia calcification; Arterial calcification due to CD73 deficiency; Hyperphosphatemic familial tumoral calcinosis; Etiology; Phenotype
Core Tip	Ectopic mineralization disorders represent a broad range of phenotypically heterogenous diseases, often leading to significant morbidity and mortality. Involving a complex interplay between different pro-osteogenic mediators and inhibitors of calcification, the mechanisms of ectopic mineralization are progressively being unveiled. Though current knowledge is beyond any doubt the tip of the proverbial iceberg, insights already have significant implications in the diagnosis and daily management of these patients. As such, ectopic mineralization diseases are a fine example of translating variome data to the clinic. Here, we will discuss prototype hereditary ectopic calcification diseases with respect to their presentation, diagnosis and management.
Publish Date	2015-07-27 18:31
Citation	De Vilder EYG, Vanakker OM. From variome to phenome: Pathogenesis, diagnosis and management of ectopic minerali­zation disorders. World J Clin Cases 2015; 3(7): 556-574
URL	http://www.wjgnet.com/2307-8960/full/v3/i7/556.htm
DOI	http://dx.doi.org/10.12998/wjcc.v3.i7.556

Full Article (PDF)	WJCC-3-556.pdf
Full Article (Word)	WJCC-3-556.doc
Manuscript File	15578-Review.docx
Answering Reviewers	15578-Answering reviewers.pdf
Audio Core Tip	15578-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	15578-Conflict-of-interest statement.pdf
Copyright License Agreement	15578-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	15578-Language certificate.pdf
Peer-review Report	15578-Peer-review(s).pdf
Scientific Misconduct Check	15578-Scientific misconduct check.pdf
Scientific Editor Work List	15578-Scientific editor work list.pdf