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6/20/2015 5:23:00 PM | Browse: 328 | Download: 373
Publication Name World Journal of Diabetes
Manuscript ID 15681
Country of Manuscript Source Brazil
Received
2014-12-04 08:54
Peer-Review Started
2014-12-04 19:03
To Make the First Decision
2014-12-26 13:12
Return for Revision
2015-01-03 15:07
Revised
2015-01-30 14:12
Second Decision
2015-04-01 15:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-04-09 16:49
Articles in Press
2015-04-09 16:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-09 13:58
Publish the Manuscript Online
2015-06-20 17:24
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Endocrinology and Metabolism
Manuscript type Review
Article Title Enterovirus and type 1 diabetes: What is the matter?
Manuscript Source Invited Manuscript
All Author List Carla Sanchez Bergamin and Sergio Atala Dib
Funding Agency and Grant Number
Correspondence To Sergio Atala Dib, MD, PhD, Department of Medicine, São Paulo Federal University, Rua Pedro de Toledo, 781 - 12 andar, Vila Clementino, São Paulo SP-04039001, Brazil. sergio.dib@unifesp.br
Keywords Virus; Enterovirus; Coxsackievirus; Type 1 diabetes mellitus; Auto-immune diabetes; Pathogenesis
Core Tip A complex interaction of genetic and en?vironmental factors can trigger the immune-mediated mechanism responsible for type 1 diabetes mellitus (T1DM) establishment. The role of environmental factors in this process has been exhaustive studied and viruses are among the most probable ones, especially enteroviruses. Improvements in enterovirus detection methods and randomized studies with patient follow-up have confirmed the importance of these viruses in the pathogenesis of T1DM. However the frequency of viruses induces autoimmunity or ?-cell destruction and the mechanisms and pathways how they increment the autoimmunity in T1DM still to be determined. Here, we review these mechanisms and all evolution in enterovirus studies and T1DM. Advances in molecular and genomic studies may facilitate the identification of pathways at earlier stages of autoimmunity when preventive and therapeutic approaches may be more effective.
Publish Date 2015-06-20 17:24
Citation Bergamin CS, Dib SA. Enterovirus and type 1 diabetes: What is the matter? World J Diabetes 2015; 6(6): 828-839
Url http://www.wjgnet.com/1948-9358/full/v6/i6/828.htm
DOI http://dx.doi.org/10.4239/wjd.v6.i6.828
Full Article (PDF) WJD-6-828.pdf
Full Article (Word) WJD-6-828.doc
Manuscript File 15681-Review.docx
Answering Reviewers 15681-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 15681-Conflict-of-interest statement.pdf
Copyright License Agreement 15681-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 15681-Langugae certificate.pdf
Peer-review Report 15681-Peer-review(s).pdf
Scientific Misconduct Check 15681-Scientific misconduct check.pdf
Scientific Editor Work List 15681-Scientific editor work list.pdf