Publication Name	World Journal of Diabetes
Manuscript ID	15681
Country	Brazil

Received	2014-12-04 08:54
Peer-Review Started	2014-12-04 19:03
To Make the First Decision	2014-12-26 13:12
Return for Revision	2015-01-03 15:07
Revised	2015-01-30 14:12
Second Decision	2015-04-01 15:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-04-09 16:49
Articles in Press	2015-04-09 16:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-09 13:58
Publish the Manuscript Online	2015-06-20 17:24

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Enterovirus and type 1 diabetes: What is the matter?
Manuscript Source	Invited Manuscript
All Author List	Carla Sanchez Bergamin and Sergio Atala Dib
Funding Agency and Grant Number
Corresponding Author	Sergio Atala Dib, MD, PhD, Department of Medicine, São Paulo Federal University, Rua Pedro de Toledo, 781 - 12 andar, Vila Clementino, São Paulo SP-04039001, Brazil. sergio.dib@unifesp.br
Key Words	Virus; Enterovirus; Coxsackievirus; Type 1 diabetes mellitus; Auto-immune diabetes; Pathogenesis
Core Tip	A complex interaction of genetic and en?vironmental factors can trigger the immune-mediated mechanism responsible for type 1 diabetes mellitus (T1DM) establishment. The role of environmental factors in this process has been exhaustive studied and viruses are among the most probable ones, especially enteroviruses. Improvements in enterovirus detection methods and randomized studies with patient follow-up have confirmed the importance of these viruses in the pathogenesis of T1DM. However the frequency of viruses induces autoimmunity or ?-cell destruction and the mechanisms and pathways how they increment the autoimmunity in T1DM still to be determined. Here, we review these mechanisms and all evolution in enterovirus studies and T1DM. Advances in molecular and genomic studies may facilitate the identification of pathways at earlier stages of autoimmunity when preventive and therapeutic approaches may be more effective.
Publish Date	2015-06-20 17:24
Citation	Bergamin CS, Dib SA. Enterovirus and type 1 diabetes: What is the matter? World J Diabetes 2015; 6(6): 828-839
URL	http://www.wjgnet.com/1948-9358/full/v6/i6/828.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i6.828

Full Article (PDF)	WJD-6-828.pdf
Full Article (Word)	WJD-6-828.doc
Manuscript File	15681-Review.docx
Answering Reviewers	15681-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15681-Conflict-of-interest statement.pdf
Copyright License Agreement	15681-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	15681-Langugae certificate.pdf
Peer-review Report	15681-Peer-review(s).pdf
Scientific Misconduct Check	15681-Scientific misconduct check.pdf
Scientific Editor Work List	15681-Scientific editor work list.pdf