Publication Name	World Journal of Stem Cells
Manuscript ID	15727
Country	Israel

Received	2014-12-06 14:57
Peer-Review Started	2014-12-06 23:24
To Make the First Decision	2015-02-07 14:52
Return for Revision	2015-02-10 11:13
Revised	2015-02-22 15:41
Second Decision	2015-03-16 18:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-04-07 16:00
Articles in Press	2015-04-07 16:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-11 14:06
Publish the Manuscript Online	2015-06-30 08:56

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Genetics & Heredity
Manuscript Type	Review
Article Title	Modeling diseases of noncoding unstable repeat expansions using mutant pluripotent stem cells
Manuscript Source	Invited Manuscript
All Author List	Shira Yanovsky-Dagan, Hagar Mor-Shaked and Rachel Eiges
Funding Agency and Grant Number
Corresponding Author	Rachel Eiges, PhD, Stem Cell Research Laboratory, Medical Genetics Institute, Shaare Zedek Medical Center affiliated with the Hebrew University School of Medicine, 12 Shmu’el Bait Street, PO Box 3235, Jerusalem 91031, Israel. rachela@szmc.org.il
Key Words	Unstable repeat associated disorders; Human embryonic stem cells; Patient-derived induced pluripotent stem cells; Disease modeling; Epigenetics; repeat-associated non-ATG translation; RNA toxicity; Repeat somatic instability
Core Tip	This review summarizes the current con?tribution of mutant pluripotent stem cells (diseased HESCs and patient-derived induced pluripotent stem cells) to the research of unstable repeat pathologies by focusing on particularly large unstable noncoding expansions. It demonstrates their importance as an unlimited cell source for gene?rating rarely available impaired cells in culture, and as a model system for exploring the mechanisms that are involved with this class of mutations. For each mechanism we describe the currently available stem cell based models, highlight how they contributed to better understanding of the related mechanism, and discuss how they may be utilized in future investigations.
Publish Date	2015-06-30 08:56
Citation	Yanovsky-Dagan S, Mor-Shaked H, Eiges R. Modeling diseases of noncoding unstable repeat expansions using mutant pluripotent stem cells. World J Stem Cells 2015; 7(5): 823-838
URL	http://www.wjgnet.com/1948-0210/full/v7/i5/823.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i5.823

Full Article (PDF)	WJSC-7-823.pdf
Full Article (Word)	WJSC-7-823.doc
Manuscript File	15727-Review.docx
Answering Reviewers	15727-Answering reviewers.pdf
Audio Core Tip	15727-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	15727-Conflict-of-interest statement.pdf
Copyright License Agreement	15727-Copyright assignment.pdf
Peer-review Report	15727-Peer-review(s).pdf
Scientific Misconduct Check	15727-Scientific misconduct check.pdf
Scientific Editor Work List	15727-Scientific editor work list.pdf