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5/13/2015 10:06:00 AM | Browse: 1072 | Download: 1270
Publication Name World Journal of Hepatology
Manuscript ID 15764
Country/Territory United States
Received
2014-12-11 10:04
Peer-Review Started
2014-12-11 15:33
To Make the First Decision
2014-12-26 13:03
Return for Revision
2014-12-31 10:37
Revised
2015-01-15 08:18
Second Decision
2015-02-27 09:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-03-09 17:30
Articles in Press
2015-03-09 17:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-04-24 10:24
Publish the Manuscript Online
2015-05-13 10:06
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy
Manuscript Source Invited Manuscript
All Author List Treta Purohit and Mitchell S Cappell
Funding Agency and Grant Number
Corresponding Author Mitchell S Cappell, MD, PhD, Division of Gastroenterology and Hepatology, William Beaumont Hospital, MOB 602, 3535 W. Thirteen Mile Road, Royal Oak, MI 48073, United States. mscappell@yahoo.com
Key Words Primary biliary cirrhosis; Ursodeoxycholic acid; Cirrhosis; Liver transplantation; Cholestatic liver disease
Core Tip Primary biliary cirrhosis (PBC) is an autoimmune, slowly progressive, cholestatic, liver disease characterized by a triad of chronic cholestasis, circulating anti-mitochondrial antibodies, and characteristic liver biopsy findings of nonsuppurative destructive cholangitis and interlobular bile duct destruction. Prominent clinical features include fatigue, pruritis, jaundice, xanthomas, osteoporosis, and dyslipidemia. Ursodeoxycholic acid is the primary therapy. Obtecholic acid and fibrate are promising new, but incompletely tested, therapies. Liver transplantation is the definitive therapy for advanced disease, with about 70% 10-year survival after trans-plantation. Complications of cirrhosis from advanced PBC include esophageal varices, ascites, spontaneous bacterial peritonitis, hepatorenal syndrome, and hepatoma formation.
Publish Date 2015-05-13 10:06
Citation Purohit T, Cappell MS. Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy. World J Hepatol 2015; 7(7): 926-941
URL http://www.wjgnet.com/1948-5182/full/v7/i7/926.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i7.926
Full Article (PDF) WJH-7-926.pdf
Full Article (Word) WJH-7-926.doc
Manuscript File 15764-Review.docx
Answering Reviewers 15764-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 15764-Conflict-of-interest statement.pdf
Copyright License Agreement 15764-Copyright assignment.pdf
Peer-review Report 15764-Peer-review(s) .pdf
Scientific Misconduct Check 15764-Scientific misconduct check.pdf
Scientific Editor Work List 15764-Scientific editor work list.pdf