Publication Name	World Journal of Hepatology
Manuscript ID	15764
Country	United States

Received	2014-12-11 10:04
Peer-Review Started	2014-12-11 15:33
To Make the First Decision	2014-12-26 13:03
Return for Revision	2014-12-31 10:37
Revised	2015-01-15 08:18
Second Decision	2015-02-27 09:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-03-09 17:30
Articles in Press	2015-03-09 17:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-24 10:24
Publish the Manuscript Online	2015-05-13 10:06

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy
Manuscript Source	Invited Manuscript
All Author List	Treta Purohit and Mitchell S Cappell
Funding Agency and Grant Number
Corresponding Author	Mitchell S Cappell, MD, PhD, Division of Gastroenterology and Hepatology, William Beaumont Hospital, MOB 602, 3535 W. Thirteen Mile Road, Royal Oak, MI 48073, United States. mscappell@yahoo.com
Key Words	Primary biliary cirrhosis; Ursodeoxycholic acid; Cirrhosis; Liver transplantation; Cholestatic liver disease
Core Tip	Primary biliary cirrhosis (PBC) is an autoimmune, slowly progressive, cholestatic, liver disease characterized by a triad of chronic cholestasis, circulating anti-mitochondrial antibodies, and characteristic liver biopsy findings of nonsuppurative destructive cholangitis and interlobular bile duct destruction. Prominent clinical features include fatigue, pruritis, jaundice, xanthomas, osteoporosis, and dyslipidemia. Ursodeoxycholic acid is the primary therapy. Obtecholic acid and fibrate are promising new, but incompletely tested, therapies. Liver transplantation is the definitive therapy for advanced disease, with about 70% 10-year survival after trans-plantation. Complications of cirrhosis from advanced PBC include esophageal varices, ascites, spontaneous bacterial peritonitis, hepatorenal syndrome, and hepatoma formation.
Publish Date	2015-05-13 10:06
Citation	Purohit T, Cappell MS. Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy. World J Hepatol 2015; 7(7): 926-941
URL	http://www.wjgnet.com/1948-5182/full/v7/i7/926.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i7.926

Full Article (PDF)	WJH-7-926.pdf
Full Article (Word)	WJH-7-926.doc
Manuscript File	15764-Review.docx
Answering Reviewers	15764-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15764-Conflict-of-interest statement.pdf
Copyright License Agreement	15764-Copyright assignment.pdf
Peer-review Report	15764-Peer-review(s) .pdf
Scientific Misconduct Check	15764-Scientific misconduct check.pdf
Scientific Editor Work List	15764-Scientific editor work list.pdf